Evidence map›Paper›PMID 33989713›Full record

ArticleJournal of the American College of Cardiology2021

Kidney Function and Outcomes in Patients Hospitalized With Heart Failure.

Ravi B Patel, Gregg C Fonarow, Stephen J Greene, Shuaiqi Zhang, Brooke Alhanti, Adam D DeVore, Javed Butler, Paul A Heidenreich, Joanna C Huang, Michelle M Kittleson and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ravi B PatelDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: https://twitter.com/RBPatelMD.
Gregg C FonarowAhmanson-University of California, Los Angeles Cardiomyopathy Center, University of California-Los Angeles, Los Angeles, California, USA. Electronic address: gfonarow@mednet.ucla.edu.
Stephen J GreeneDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA. Electronic address: https://twitter.com/SJGreene_md.
Shuaiqi ZhangDuke Clinical Research Institute, Durham, North Carolina, USA.
Brooke AlhantiDuke Clinical Research Institute, Durham, North Carolina, USA.
Adam D DeVoreDivision of Cardiology, Duke University School of Medicine, Durham, North Carolina, USA; Duke Clinical Research Institute, Durham, North Carolina, USA. Electronic address: https://twitter.com/_adevore.
Javed ButlerDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA. Electronic address: https://twitter.com/JavedButler1.
Paul A HeidenreichDivision of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Joanna C HuangAstraZeneca, Wilmington, Delaware, USA.
Michelle M KittlesonDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai, Los Angeles, California, USA. Electronic address: https://twitter.com/MKIttlesonMD.
Karen E Joynt MaddoxDepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, St Louis, Missouri, USA. Electronic address: https://twitter.com/kejoynt.
James J McDermottAstraZeneca, Wilmington, Delaware, USA.
Anjali Tiku OwensHeart and Vascular Center, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: https://twitter.com/tikuowens.
Pamela N PetersonDepartment of Medicine, Denver Health Medical Center, Denver, Colorado, USA; Department of Medicine, Anschutz Medical Center, Aurora, Colorado, USA.
Scott D SolomonDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: https://twitter.com/scottdsolomon.
Orly VardenyCenter for Care Delivery and Outcomes Research, Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minnesota, USA. Electronic address: https://twitter.com/orlyvardeny.
Clyde W YancyDivision of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Muthiah VaduganathanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: https://twitter.com/mvaduganathan.

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1M
Enhancing cardiac and pulmonary rehabilitation adherence through home-based rehabilitation and behavioral nudges: ERA NudgeR33HL143324 · NHLBI · DENVER HEALTH AND HOSPITAL AUTHORITY · PI PETERSON, PAMELA N · 2019 to 2022
$2.9M
NCATS NIH HHS KL2 TR001424NHLBI NIH HHS R33 HL143324
6 · The paper itself

Abstract

backgroundFew contemporary data exist evaluating care patterns and outcomes in heart failure (HF) across the spectrum of kidney function.

objectivesThis study sought to characterize differences in quality of care and outcomes in patients hospitalized for HF by degree of kidney dysfunction.

methodsGuideline-directed medical therapies were evaluated among patients hospitalized with HF at 418 sites in the GWTG-HF (Get With The Guidelines-Heart Failure) registry from 2014 to 2019 by discharge CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)-derived estimated glomerular filtration rate (eGFR). We additionally evaluated the risk-adjusted association of admission eGFR with in-hospital mortality.

resultsAmong 365,494 hospitalizations (age 72 ± 15 years, left ventricular ejection fraction [EF]: 43 ± 17%), median discharge eGFR was 51 ml/min/1.73 m

conclusionsDespite facing elevated risks of mortality, patients with comorbid HF with reduced EF and kidney disease are not optimally treated with evidence-based medical therapies, even at levels of eGFR where such therapies would not be contraindicated by kidney dysfunction. Further efforts are required to mitigate risk in comorbid HF and kidney disease.

Indexed as

Quality ImprovementRegistriesAgedComorbidityFemaleFollow-Up StudiesGlomerular Filtration RateHeart FailureHospitalizationHumansKidneyMaleMiddle AgedRenal Insufficiency, ChronicRetrospective StudiesUnited Statesglomerular filtration rateheart failurekidney diseaseoutcomestherapy

Identifiers

PMID33989713
PMCPMC8994871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.