Trial reportOphthalmology2021
Pneumatic Vitreolysis with Perfluoropropane for Vitreomacular Traction with and without Macular Hole: DRCR Retina Network Protocols AG and AH.
Trial report in Ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Efficacy and Safety of Ocriplasmin Use for Vitreomacular Adhesion and Its Predictive Factors: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Mechanisms of Gas-Induced Posterior Vitreous Detachment: A Look Behind the Bubble Using Optical Coherence Tomography in Prone Position.Journal of clinical medicine · 2026Article
- Vitrectomy in Small idiopathic MAcuLar hoLe (SMALL) study: Internal limiting membrane peeling versus no peeling.Acta ophthalmologica · 2025Article
- Minimal Gas Vitrectomy and As-Needed Positioning Duration for Idiopathic Macular Holes.Ophthalmology and therapy · 2025Article
- Intravitreal C3F8 versus SF6: effects on corneal tomography parameters and intraocular pressure in vitreomacular traction treatment.International ophthalmology · 2025Article
- Vitreomacular traction - a review.Eye (London, England) · 2025Review
- Single-arm clinical trials: design, ethics, principles.BMJ supportive & palliative care · 2024Review
- Vitrectomy in Small idiopathic MAcuLar hoLe (SMALL) study: conventional internal limiting membrane peeling versus inverted flap.Eye (London, England) · 2024Article
- [Current treatment strategies for vitreomacular traction and macular holes: a survey of retinal specialists in Germany].Die Ophthalmologie · 2024Article
- [Macular hole: Differential diagnosis, treatment options and new guideline recommendations].Die Ophthalmologie · 2024Review
- [Vitreomacular traction: diagnostics, natural course, treatment decision and guideline recommendations].Die Ophthalmologie · 2024Review
- Gas tamponade followed by laser treatment for macular retinal detachment secondary to optic pit.Arquivos brasileiros de oftalmologia · 2023Article
- Macular hole closure induced by intravitreal injection in diabetic macular edema.International journal of ophthalmology · 2022Article
- Article
- Prevalence and Associations of Vitreomacular Traction: The Beijing Eye Study.International journal of general medicine · 2021Article
- Pars Plana Vitrectomy for Vitreomacular Traction Resulting in Persistent Postoperative Loculated Foveal Subretinal Fluid.Journal of vitreoretinal diseasesArticle
- Resolution of Vitreomacular Traction Following a Commercial Flight Simulator Experience.Journal of vitreoretinal diseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 12 institutions in 1 country.
Funding
Abstract
purposeTo evaluate pneumatic vitreolysis (PVL) in eyes with vitreomacular traction (VMT) with and without full-thickness macular hole (FTMH).
designTwo multicenter (28 sites) studies: a randomized clinical trial comparing PVL with observation (sham injection) for VMT without FTMH (Protocol AG) and a single-arm study assessing PVL for FTMH (Protocol AH).
participantsParticipants were adults with central VMT (vitreomacular adhesion was ≤3000 μm). In Protocol AG, visual acuity (VA) was 20/32 to 20/400. In Protocol AH, eyes had a FTMH (≤250 μm at the narrowest point) and VA of 20/25 to 20/400.
methodsPneumatic vitreolysis using perfluoropropane (C
main outcome measuresCentral VMT release at 24 weeks (Protocol AG) and FTMH closure at 8 weeks (Protocol AH).
resultsFrom October 2018 through February 2020, 46 participants were enrolled in Protocol AG, and 35 were enrolled in Protocol AH. Higher than expected rates of retinal detachment and tear resulted in early termination of both protocols. Combining studies, 7 of 59 eyes (12% [95% CI, 6%-23%]; 2 eyes in Protocol AG, 5 eyes in Protocol AH) that received PVL developed rhegmatogenous retinal detachment (n = 6) or retinal tear (n = 1). At 24 weeks in Protocol AG, 18 of 23 eyes in the PVL group (78%) versus 2 of 22 eyes in the sham group (9%) achieved central VMT release without rescue vitrectomy (adjusted risk difference, 66% [95% CI, 44%-88%]; P< 0.001). The mean change in VA from baseline at 24 weeks was 6.7 letters in the PVL group and 6.1 letters in the sham group (adjusted difference, -0.8 [95% CI, -6.1 to 4.5]; P = 0.77). In Protocol AH, 10 of 35 eyes (29% [95% CI, 16%-45%]) achieved FTMH closure without rescue vitrectomy at 8 weeks. The mean change in VA from baseline at 8 weeks was -1.5 letters (95% CI, -10.3 to 7.3 letters).
conclusionsIn most eyes with VMT, PVL induced hyaloid release. In eyes with FTMH, PVL resulted in hole closure in approximately one third of eyes. These studies were terminated early because of safety concerns related to retinal detachments and retinal tears.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.