Evidence map›Paper›PMID 33989634›Full record

ArticleThe Journal of biological chemistry

The molecular basis for the pH-dependent calcium affinity of the pattern recognition receptor langerin.

Jan-O Joswig, Jennifer Anders, Hengxi Zhang, Christoph Rademacher, Bettina G Keller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. GPU-Accelerated Implementation of Constant-pH Molecular Dynamics in NAMD.Journal of chemical information and modeling · 2025
    Article
  3. Article
  4. Allosterically switchable network orientsProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Secondary Sites of the C-type Lectin-Like Fold.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jan-O JoswigDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany.
Jennifer AndersDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany.
Hengxi ZhangDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany; Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria; Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria.
Christoph RademacherDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany; Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria; Max F. Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria.
Bettina G KellerDepartment of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany. Electronic address: bettina.keller@fu-berlin.de.
Freie Universität Berlin · DEUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Langerin requires a Ca

Indexed as

Antigens, CDBinding SitesCalciumHumansHydrogen-Ion ConcentrationLectins, C-TypeMannose-Binding LectinsModels, MolecularProtein BindingProtein DomainsProtein StabilityProtonsAntigens, CDCalciumCD207 protein, humanLectins, C-TypeMannose-Binding LectinsProtonsallosteric regulationcalcium-binding proteincomputer modelingconformational changemolecular dynamicspattern recognition receptor (PRR)pH regulation

Identifiers

PMID33989634
PMCPMC8219899
OpenAlexW3161639839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.