SynthesisEnvironmental research2021
Ozone exposure during early pregnancy and preterm birth: A systematic review and meta-analysis.
Synthesis in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Susceptible window identification of the relationship between maternal ozone exposure and preterm birth.International health · 2026Pooled it
- Comparison of machine learning methods versus traditional Cox regression for survival prediction in cancer using real-world data: a systematic literature review and meta-analysis.BMC medical research methodology · 2025Pooled it
- Linking mixtures of air pollution exposures and preterm birth with a self-organizing map.Journal of exposure science & environmental epidemiology · 2026Article
- Fine Particulate Exposure During Pregnancy Impacts on Perinatal Complications in Deeply Phenotyped Preterm Infants With Significant Immaturity.Pulmonary circulation · 2026Article
- Interactive and joint associations of prenatal ozone and PMBMC public health · 2025Article
- Machine learning-based prediction algorithm of spontaneous preterm birth using multi-source data.BMC pregnancy and childbirth · 2025Article
- The impact of extreme air pollution on preterm birth in twin pregnancies: identifying susceptible exposure windows.Annals of medicine · 2025Article
- Article
- Potential impact of air pollution on polycystic ovary syndrome incidence: a global analysis of 171 countries and regions from 1990 to 2021.Journal of ovarian research · 2025Article
- Article
- Ambient Air Pollution and Congenital Heart Disease: Updated Evidence and Future Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Ambient temperature and ozone exposure increases the risk of preterm birth in Northeast China: a time series analysis.Frontiers in public health · 2025Article
- Impact of climate change and environmental adversities on maternal and fetal health: the role of clinical practices and providers in mitigating effects and prioritising women's health in the UK.Frontiers in global women's health · 2025Review
- Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO.Environmental epigenetics · 2025Article
- Long-term ambient sulfur dioxide exposure during gestation and preterm birth in North Carolina, 2003-2015.Atmospheric environment (Oxford, England : 1994) · 2024Article
- Article
- Long-term exposure to air pollution on cardio-respiratory, and lung cancer mortality: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2024Review
- The association between pregnancy levels of blood lipids and the risk of preterm birth.Scientific reports · 2024Article
- Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms.BJOG : an international journal of obstetrics and gynaecology · 2024Review
- Systems for rating bodies of evidence used in systematic reviews of air pollution exposure and reproductive and children's health: a methodological survey.Environmental health : a global access science source · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to ozone has been linked to reproductive outcomes, including preterm birth. In this systematic review, we summarize published epidemiologic cohort and case-control studies examining ozone exposures (estimated on a continuous scale) in early pregnancy (1st and 2nd trimesters (T1, T2)) and preterm birth using ratio measures, and perform a meta-analysis to evaluate the potential relationship between them. Studies were identified by searching PubMed and Web of Science, screened according to predefined inclusion/exclusion criteria, and evaluated for study quality. We extracted study data including effect estimates, confidence limits, study location, study years, ozone exposure assessment method, and mean or median ozone concentrations. Nineteen studies were identified and included, of which 18 examined T1 exposure (17 reported effect estimates), and 15 examined T2 exposure. Random effects meta-analysis was performed in the metafor package, R 3.5.3. The pooled OR (95% CI) for a 10 ppb increase in ozone exposure in T1 was 1.06 (1.03, 1.10) with a 95% prediction interval of 0.95, 1.19; for T2 it was 1.05 (1.02, 1.08) with a 95% prediction interval of 0.95, 1.16. Effect estimates for both exposure periods showed high heterogeneity. In meta-regression analyses of study characteristics, study location (continent) explained some (~20%) heterogeneity for T1 exposure studies, but no characteristic explained a substantial amount of heterogeneity for T2 exposure studies. Increased ozone exposure during early pregnancy is associated with preterm birth across studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.