Evidence map›Paper›PMID 33989527›Full record

ArticleCurrent biology : CB2021

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.

Anil Kumar Ganga, Margaret C Kennedy, Mai E Oguchi, Shawn Gray, Kendall E Oliver, Tracy A Knight, Enrique M De La Cruz, Yuta Homma, Mitsunori Fukuda, David K Breslow

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
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  7. Mammalian evolution and human mutation burden in Rab GTPases.Biochemistry and biophysics reports · 2026
    Article
  8. Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell-cell junctions during neural tube formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Anil Kumar GangaDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Margaret C KennedyDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Mai E OguchiLaboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Shawn GrayDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Kendall E OliverDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Tracy A KnightDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Enrique M De La CruzDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.
Yuta HommaLaboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
Mitsunori FukudaLaboratory of Membrane Trafficking Mechanisms, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
David K BreslowDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA. Electronic address: david.breslow@yale.edu.
Yale University · USTohoku University · JP

Funding

Actin filament mechanics and branched network turnoverR35GM136656 · NIGMS · YALE UNIVERSITY · PI ENRIQUE M DE LA CRUZ · 2020 to 2026
$4.0M
Mechanisms of Primary Cilium Assembly and DisassemblyR35GM137956 · NIGMS · YALE UNIVERSITY · PI David King Breslow · 2020 to 2026
$3.1M
Ciliary control of Gli protein activity in Hedgehog pathway signalingR00HD082280 · NICHD · YALE UNIVERSITY · PI BRESLOW, DAVID KING · 2017 to 2019
$731k
NICHD NIH HHS R00 HD082280NIGMS NIH HHS R35 GM136656NIGMS NIH HHS R35 GM137956
6 · The paper itself

Abstract

The primary cilium is an essential organizing center for signal transduction, and ciliary defects cause congenital disorders known collectively as ciliopathies.

Indexed as

AnimalsCell LineCell MembraneCentriolesCiliaDogsHumansHydrolysisMiceNuclear Proteinsrab GTP-Binding ProteinsSignal TransductionNuclear ProteinsRAB34 protein, humanRab34 protein, mouserab GTP-Binding Proteinscentrioleciliaciliary vesicleciliogenesisciliopathyGTPasemembraneRab

Identifiers

PMID33989527
PMCPMC8282722
OpenAlexW3163340607

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.