ArticleCell metabolism2021
Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver.
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Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Decoding cancer across scales with metabolomics.Nature reviews. Cancer · 2026Review
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- Analysis of Plasma Biomarkers and Potential Pathogenesis in Children withInfection and drug resistance · 2026Article
- Transient exposure to bisphenol F in early life affects the metabolic health of adults.Exposome · 2026Article
- Intestine-derived sorbitol drives steatotic liver disease in the absence of gut bacteria.Science signaling · 2025Article
- Preoptic activation induces a torpor-like hypothermic and hypometabolic state that is cerebroprotective.bioRxiv : the preprint server for biology · 2025Article
- Integrated single-cell sequencing for the development of a GJA4-based precision immuno-prognostic model in melanoma.Translational oncology · 2025Article
- Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk.Nature communications · 2025Article
- Zebrafish metabolomics: a comprehensive approach to understanding health and disease.Functional & integrative genomics · 2025Review
- Stable-isotope tracing reveals the role of corticosteroid receptors in driving cortisol-mediated central and peripheral glucose regulation in zebrafish.Frontiers in endocrinology · 2025Article
- Preliminary investigation of gut microbiota and associated metabolic pathways in the pathogenesis of primary central nervous system lymphoma.Frontiers in oncology · 2025Article
- Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes.Computational and structural biotechnology journal · 2025Article
- Article
- A comprehensive review of animal models for cancer cachexia: Implications for translational research.Genes & diseases · 2024Review
- Phospholipid isotope tracing suggests β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2024Article
- Stable Isotope Tracing Analysis in Cancer Research: Advancements and Challenges in Identifying Dysregulated Cancer Metabolism and Treatment Strategies.Metabolites · 2024Review
- Article
- Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma.bioRxiv : the preprint server for biology · 2023Article
- Review
- Rethinking our approach to cancer metabolism to deliver patient benefit.British journal of cancer · 2023Review
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Authors and funding
16 authors at 2 institutions in 1 country.
Fuad J NaserDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Madelyn M JackstadtDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Ronald Fowle-GriderDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Jonathan L SpaldingDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA.
Kevin ChoDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Ethan StancliffeDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Steven R DoonanDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Eva T KramerDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Division of Medical Oncology, Washington University in St. Louis, St. Louis, MO, USA; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA.
Lijun YaoDepartment of Genetics, Washington University in St. Louis, St. Louis, MO, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.
Bradley KrasnickSiteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA; Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA.
Li DingDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.
Ryan C FieldsSiteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA; Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA.
Charles K KaufmanDepartment of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Division of Medical Oncology, Washington University in St. Louis, St. Louis, MO, USA; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.
Leah P ShriverDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Stephen L JohnsonDepartment of Genetics, Washington University in St. Louis, St. Louis, MO, USA; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA.
Gary J PattiDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: gjpattij@wustl.edu.
Washington University in St. Louis · USJames S. McDonnell Foundation · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MDeveloping Metabolomic Technologies to Advance Environmental Exposure AnalysisR35ES028365 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2017 to 2024
$5.9MA COMPREHENSIVE RESOURCE FOR HIGH-THROUGHPUT PROFILING OF WORM AND ZEBRAFISH METABOLOMESR24OD024624 · OD · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2018 to 2021
$4.0MA Comprehensive Platform for High-Throughput Profiling of the Human Reference MetabolomeU01CA235482 · NCI · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2018 to 2021
$1.8MNCATS NIH HHS L30 TR000589NCI NIH HHS U01 CA235482NIDDK NIH HHS P30 DK056341NIEHS NIH HHS R35 ES028365NIH HHS R24 OD024624
Abstract
The cell-intrinsic nature of tumor metabolism has become increasingly well characterized. The impact that tumors have on systemic metabolism, however, has received less attention. Here, we used adult zebrafish harboring BRAF
Indexed as
AgingAlanineAnimalsAnimals, Genetically ModifiedCell TrackingDisease Models, AnimalGluconeogenesisHumansIsotope LabelingLiverLiver NeoplasmsMelanomaMetabolomicsZebrafishAlaninealanine cyclecancercancer metabolismisotope tracingmelanomametabolite exchangemetabolomicszebrafish
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.