Evidence map›Paper›PMID 33989511›Full record

ReviewHuman vaccines & immunotherapeutics2021

The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy.

Sylvia Annabel Dass, Rehasri Selva Rajan, Gee Jun Tye, Venugopal Balakrishnan

Open access · bronzeAbstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sylvia Annabel DassInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, George Town, Malaysia.ORCID 0000-0002-8167-5514
Rehasri Selva RajanInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, George Town, Malaysia.ORCID 0000-0001-7863-3965
Gee Jun TyeInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, George Town, Malaysia.ORCID 0000-0002-6707-9505
Venugopal BalakrishnanInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, George Town, Malaysia.ORCID 0000-0002-4874-600X
Universiti Sains Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is ranked as the fourth most common cancer in women worldwide. Monoclonal antibody has created a new dimension in the immunotherapy of many diseases, including cervical cancer. The antibody's ability to target various aspects of cervical cancer (oncoviruses, oncoproteins, and signaling pathways) delivers a promising future for efficient immunotherapy. Besides, technologies such as hybridoma and phage display provide a fundamental platform for monoclonal antibody generation and create the opportunity to generate novel antibody classes including, T cell receptor (TCR)-like antibody. In this review, the current immunotherapy strategies for cervical cancer are presented. We have also proposed a novel concept of T cell receptor (TCR)-like antibody and its potential applications for enhancing cervical cancer therapeutics. Finally, the possible challenges in TCR-like antibody application for cervical cancer therapeutics have been addressed, and strategies to overcome the challenges have been highlighted to maximize the therapeutic benefits.

Indexed as

Uterine Cervical NeoplasmsAntibodies, MonoclonalFemaleHumansImmunologic FactorsImmunotherapyReceptors, Antigen, T-CellAntibodies, MonoclonalImmunologic FactorsReceptors, Antigen, T-CellAntibody therapycervical cancerhuman papillomavirusmonoclonalphage display technologyT cell receptor (TCR)-mimic antibody

Identifiers

PMID33989511
PMCPMC8381793
OpenAlexW3161856948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.