Evidence map›Paper›PMID 33989505›Full record

Observational studyAmerican journal of speech-language pathology2021

Early Observation of Red Flags in 12-Month-Old Infant Siblings Later Diagnosed With Autism Spectrum Disorder.

Moira L Pileggi, Natalie Brane, Jessica Bradshaw, Abigail Delehanty, Taylor Day, Courtney McCracken, Jennifer Stapel-Wax, Amy M Wetherby

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in American journal of speech-language pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Neonatal autonomic regulation as a predictor of autism symptoms in very preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  3. Article
  4. The influence of loss to follow-up in autism screening research: Taking stock and moving forward.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Moira L PileggiMarcus Autism Center, Children's Healthcare of Atlanta, GA.
Natalie BraneMarcus Autism Center, Children's Healthcare of Atlanta, GA.
Jessica BradshawDepartment of Psychology, University of South Carolina, Columbia.
Abigail DelehantyDepartment of Speech-Language Pathology, Duquesne University, Pittsburgh, PA.
Taylor DayDepartment of Psychology, Florida State University, Tallahassee.
Courtney McCrackenDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Jennifer Stapel-WaxDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Amy M WetherbyDepartment of Clinical Sciences, Florida State University, Tallahassee.
Google (United States) · USFlorida State University · US

Funding

The ontogeny of social vocal engagement and its derailment in autismP50MH100029 · NIMH · EMORY UNIVERSITY · PI WETHERBY, AMY M · 2012 to 2021
$20.1M
Smart Early Screening for Autism and Communication Disorders in Primary CareR01HD078410 · NICHD · FLORIDA STATE UNIVERSITY · PI WETHERBY, AMY M · 2014 to 2018
$2.5M
Heart Defined Attention in Infancy: Predicting Social Communication and ASD SymptomologyK23MH120476 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2019 to 2023
$939k
Neurobehavioral Determinants of Social Communication and Language Impairments in at - Risk InfantsR21DC017252 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2020 to 2022
$427k
NICHD NIH HHS R01 HD078410NIDCD NIH HHS R21 DC017252NIMH NIH HHS K23 MH120476NIMH NIH HHS P50 MH100029
6 · The paper itself

Abstract

Purpose Valid and reliable screening tools are needed to improve early detection and optimize developmental outcomes for toddlers at risk for autism spectrum disorder (ASD). The current study aimed to evaluate the utility of the Systematic Observation of Red Flags (SORF) for ASD at 12 months of age in a sample of high-risk infant siblings of children with ASD. Method As part of a prospective, longitudinal study, we examined the sensitivity and specificity of the SORF at 12 months for predicting a diagnosis of ASD at 24 months in a sample of 122 infants, 31 of whom were diagnosed with ASD. Results The optimal SORF Composite cutoff score of 18 correctly identified 24 of the 31 twelve-month-olds who were diagnosed with ASD, yielding a sensitivity of .77 and a specificity of .76. The optimal SORF Red Flags cutoff score of 7 correctly identified 20 of the 31 infants, yielding a sensitivity of .65 and a specificity of .75. Conclusion This preliminary study demonstrates the potential of the SORF as an effective observational screening measure for 12-month-olds at risk for ASD with good discrimination, sensitivity, and specificity.

Indexed as

Autism Spectrum DisorderHumansInfantLongitudinal StudiesProspective StudiesSiblings

Identifiers

PMID33989505
PMCPMC8702865
OpenAlexW3162653780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.