Evidence map›Paper›PMID 33989382›Full record

ReviewCardiovascular research2021

Neuroscientific therapies for atrial fibrillation.

Peter Hanna, Eric Buch, Stavros Stavrakis, Christian Meyer, John D Tompkins, Jeffrey L Ardell, Kalyanam Shivkumar

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05753644 (The Effect of Preoperative Stellate Ganglion Block on Postoperative Atrial Fibrillation After Video-assisted Thoracoscopic Surgeries), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05753644 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Preoperative Stellate Ganglion Block on Postoperative Atrial Fibrillation After Video-assisted Thoracoscopic Surgeries: A Randomized Controlled Trial

TypeinterventionalSponsorPeking University People's HospitalRan2023 to 2024Enrolled480ConditionsAtrial FibrillationArmsstellate ganglion blocks, Ropivacaine, Sham treatment
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Beyond the beats: a systematic review of the underlying inflammatory pathways between atrial fibrillation and cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Translational approach to ventricular innervation: the posterior descending ganglionated plexus.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  12. Review
  13. Baroreceptor reflex after pulmonary vein isolation assessed by tilt table test: adding another piece to the puzzle.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  14. The impact of the clinical diagnosis on the vagal response and heart rate after ganglionated plexus ablation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  15. Article
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  17. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Peter HannaUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA.ORCID 0000-0003-3092-5090
Eric BuchUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA.
Stavros StavrakisHeart Rhythm Institute, University of Oklahoma Health Sciences Center, 1100 N Lindsay Ave, Oklahoma City, OK 73104, USA.ORCID 0000-0002-4370-8135
Christian MeyerDivision of Cardiology, cardiac Neuro- and Electrophysiology Research Consortium (cNEP), EVK Düsseldorf, Teaching Hospital University of Düsseldorf, Kirchfeldstraße 40, 40217 Düsseldorf, Germany.ORCID 0000-0003-0217-3960
John D TompkinsUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA.ORCID 0000-0001-9496-7930
Jeffrey L ArdellUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA.ORCID 0000-0001-9241-0864
Kalyanam ShivkumarUniversity of California Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, UCLA, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USDüsseldorf University Hospital · DEUniversity of Oklahoma Health Sciences Center · US

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
Bioelectric monitoring and control of the heartU01EB025138 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2017 to 2020
$4.0M
The First Step toward a Neuronal Pacemaker of the HeartF32HL152609 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HANNA, PETER · 2020 to 2020
$80k
NHLBI NIH HHS F32 HL152609NIBIB NIH HHS U01 EB025138NIH HHS OT2 OD023848
6 · The paper itself

Abstract

The cardiac autonomic nervous system (ANS) plays an integral role in normal cardiac physiology as well as in disease states that cause cardiac arrhythmias. The cardiac ANS, comprised of a complex neural hierarchy in a nested series of interacting feedback loops, regulates atrial electrophysiology and is itself susceptible to remodelling by atrial rhythm. In light of the challenges of treating atrial fibrillation (AF) with conventional pharmacologic and myoablative techniques, increasingly interest has begun to focus on targeting the cardiac neuraxis for AF. Strong evidence from animal models and clinical patients demonstrates that parasympathetic and sympathetic activity within this neuraxis may trigger AF, and the ANS may either induce atrial remodelling or undergo remodelling itself to serve as a substrate for AF. Multiple nexus points within the cardiac neuraxis are therapeutic targets, and neuroablative and neuromodulatory therapies for AF include ganglionated plexus ablation, epicardial botulinum toxin injection, vagal nerve (tragus) stimulation, renal denervation, stellate ganglion block/resection, baroreceptor activation therapy, and spinal cord stimulation. Pre-clinical and clinical studies on these modalities have had promising results and are reviewed here.

Indexed as

Autonomic DenervationElectric Stimulation TherapyAction PotentialsAnimalsAnti-Arrhythmia AgentsAtrial FibrillationAtrial RemodelingAutonomic Nervous SystemHeartHeart RateHumansNeurotransmitter AgentsSpinal Cord StimulationTreatment OutcomeVagus Nerve StimulationAnti-Arrhythmia AgentsNeurotransmitter AgentsAtrial fibrillationAutonomic nervous systemNeurocardiologyNeuromodulationVagus nerve

Identifiers

PMID33989382
PMCPMC8208752
OpenAlexW3163344635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.