Evidence map›Paper›PMID 33989353›Full record

Trial reportPloS one2021

Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.

Nirupama Shivakumar, Ambily Sivadas, Sarita Devi, Farook Jahoor, John McLaughlin, Craig P Smith, Anura V Kurpad, Arpita Mukhopadhyay

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Current Understanding ofCurrent tropical medicine reports · 2024
    Article
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Nirupama ShivakumarDivision of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
Ambily SivadasDivision of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
Sarita DeviDivision of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
Farook JahoorDepartment of Pediatrics, USDA/Agricultural Research Service Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States of America.
John McLaughlinFaculty of Biology, Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester, Clinical Sciences Building, Salford Royal Hospital, Salford, United Kingdom.
Craig P SmithFaculty of Biology, Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Medicine & Health, Manchester Academic Health Sciences Centre, University of Manchester, Clinical Sciences Building, Salford Royal Hospital, Salford, United Kingdom.
Anura V KurpadDivision of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
Arpita MukhopadhyayDivision of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.ORCID 0000-0001-8260-5385
St. John's National Academy of Health Sciences · INUniversity of Manchester · GBAgricultural Research Service · US

Funding

Medical Research Council MC_PC_MR/R019118/1
6 · The paper itself

Abstract

Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth.

Indexed as

BacteriaChild DevelopmentGastrointestinal MicrobiomeSex CharacteristicsChild, PreschoolFemaleHumansInfantMale

Identifiers

PMID33989353
PMCPMC8121364
OpenAlexW3161423991

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.