Evidence map›Paper›PMID 33989295›Full record

ArticlePloS one2021

Synergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains.

Awais Khalid, Pervaiz Ahmad, Abdulrahman I Alharthi, Saleh Muhammad, Mayeen Uddin Khandaker, Mohammad Rashed Iqbal Faruque, Israf Ud Din, Mshari A Alotaibi, Abdulhameed Khan

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Awais KhalidDepartment of Physics, Hazara University, Mansehra, Pakistan.
Pervaiz AhmadDepartment of Physics, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0003-3969-1489
Abdulrahman I AlharthiDepartment of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Saleh MuhammadDepartment of Physics, Hazara University, Mansehra, Pakistan.
Mayeen Uddin KhandakerCenter for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Selangor, Malaysia.
Mohammad Rashed Iqbal FaruqueSpace Science Centre, Universiti Kebangsaan Malaysia (UKM), Selangor, Malaysia.
Israf Ud DinDepartment of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Mshari A AlotaibiDepartment of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Abdulhameed KhanDepartment of Biotechnology, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.
Prince Sattam Bin Abdulaziz University · SAHazara University · PKUniversity of Azad Jammu and Kashmir · PKNational University of Malaysia · MYSunway University · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor's mixture of Copper-II chloride dihydrate (CuCl2.2H2O), Zinc chloride (ZnCl2), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported the hexagonal wurtzite structure of the synthesized Cu-doped ZnO-NPs. The surface morphology is checked via field emission scanning electron microscopy (FE-SEM), whereas, the elemental compositions of the samples were confirmed by Raman, and X-ray photoelectron spectroscopy (XPS), respectively. The as-obtained ZnO-NPs and Cu-doped ZnO-NPs were then tested for their antibacterial activity against clinical isolates of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Klebsiella pneumonia) bacteria via agar well diffusion method. The zone of inhibition (ZOI) for Cu-doped ZnO-NPs was found to be 24 and 19 mm against S. Aureus and S. pyogenes, and 18 and 11 mm against E. coli and K. pneumoniae, respectively. The synthesized Cu-doped ZnO-NPs can thus be found as a potential nano antibiotic against Gram-positive multi-drug resistant bacterial strains.

Indexed as

Anti-Bacterial AgentsCopperDrug Resistance, Multiple, BacterialEscherichia coliHumansKlebsiella pneumoniaeMetal NanoparticlesMicrobial Sensitivity TestsStaphylococcus aureusStreptococcus pyogenesZinc OxideAnti-Bacterial AgentsCoppercupric chloridecuprous oxideZinc Oxide

Identifiers

PMID33989295
PMCPMC8121369
OpenAlexW3163259623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.