ArticlePLoS genetics2021
Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- The loss of COP1 delays senescence and inhibits root growth through modulation of sucrose allocation and availability.Plant physiology · 2026Article
- Brassinosteroids promote sugar synthesis by inhibiting BIN2 phosphorylation of phosphoenolpyruvate carboxykinase.Nature plants · 2026Article
- Brassinosteroids boost sugar production by inhibiting PCK phosphorylation.Nature plants · 2026Article
- A B-box protein BReaks brassinosteroid regulation of photomorphogenesis in the dark and light.Plant physiology · 2026Article
- Brachypodium HISTONE DEACETYLASE 19.1 promotes yield, flowering, and freezing tolerance at the expense of drought tolerance.BMC plant biology · 2026Article
- Brassinosteroids promote sugar synthesis by inhibiting BIN2 phosphorylation of phosphoenolpyruvate carboxykinase.bioRxiv : the preprint server for biology · 2025Article
- UPL3 promotes BZR1 degradation, growth arrest, and seedling survival under starvation stress in Arabidopsis.Plant communications · 2025Article
- Starch metabolism in guard cells: At the intersection of environmental stimuli and stomatal movement.Plant physiology · 2024Review
- Soybean hypocotyl elongation is regulated by a MYB33-SWEET11/21-GA2ox8c module involving long-distance sucrose transport.Plant biotechnology journal · 2024Article
- Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics.The Plant cell · 2023Article
- TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development.Journal of experimental botany · 2022Review
- EARLY FLOWERING 3 represses the nighttime growth response to sucrose in Arabidopsis.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022Article
- Identification of sugar transporter (SWEET) genes involved in pomegranate seed coat sugar accumulation.3 Biotech · 2022Article
- Increasing Sugar Content in Source for Biofuel Production Using Agrochemical and Genetic Approaches at the Stages of BioMass Preharvesting and Harvesting.Molecules (Basel, Switzerland) · 2022Review
- Glycogen synthase kinases in model and crop plants - From negative regulators of brassinosteroid signaling to multifaceted hubs of various signaling pathways and modulators of plant reproduction and yield.Frontiers in plant science · 2022Review
- Exogenous Application of Low-Concentration Sugar Enhances Brassinosteroid Signaling for Skotomorphogenesis by Promoting BIN2 Degradation.International journal of molecular sciences · 2021Article
- Signalling and regulation of plant development by carbon/nitrogen balance.Physiologia plantarumReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
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Abstract
Sugar, light, and hormones are major signals regulating plant growth and development, however, the interactions among these signals are not fully understood at the molecular level. Recent studies showed that sugar promotes hypocotyl elongation by activating the brassinosteroid (BR) signaling pathway after shifting Arabidopsis seedlings from light to extended darkness. Here, we show that sugar inhibits BR signaling in Arabidopsis seedlings grown under light. BR induction of hypocotyl elongation in seedlings grown under light is inhibited by increasing concentration of sucrose. The sugar inhibition of BR response is correlated with decreased effect of BR on the dephosphorylation of BZR1, the master transcription factor of the BR signaling pathway. This sugar effect is independent of the sugar sensors Hexokinase 1 (HXK1) and Target of Rapamycin (TOR), but requires the GSK3-like kinase Brassinosteroid-Insensitive 2 (BIN2), which is stabilized by sugar. Our study uncovers an inhibitory effect of sugar on BR signaling in plants grown under light, in contrast to its promotive effect in the dark. Such light-dependent sugar-BR crosstalk apparently contributes to optimal growth responses to photosynthate availability according to light-dark conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.