SynthesisScandinavian journal of gastroenterology2021
A bimodal pattern of the onset of COVID-19 related acute pancreatitis supports both the cytotoxic and immune-related pathogenesis - a systematic review.
Synthesis in Scandinavian journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- COVID-19-Induced Acute Pancreatitis: Clinical Profiles, Outcomes, and Prognostic Indicators From a Global Review-Based Synthesis.Health science reports · 2025Article
- Gastrointestinal Imaging Findings in the Era of COVID-19: A Pictorial Review.Medicina (Kaunas, Lithuania) · 2023Review
- COVID-19 and the Pancreas: A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Acute Pancreatitis Related to COVID-19 Infection: A Systematic Review and Analysis of Data.Cureus · 2022Review
- Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns.Diagnostics (Basel, Switzerland) · 2022Review
- Acute pancreatitis in SARS-CoV-2 infection: A case report from Tanzania.SAGE open medical case reports · 2022Article
- Gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods.Journal of digestive diseases · 2021Review
- Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings.Gastroenterology research and practice · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo review clinical and laboratory findings in patients with SARS-Cov-2 (COVID-19) related acute pancreatitis.
methodsThis systematic review was based on a database search for articles of COVID-19 related acute pancreatitis in adult patients with confirmed COVID-19 infection that included age, gender, presenting symptoms, the onset of symptoms, laboratory values, imaging findings and exclusion of common causes of pancreatitis.
resultsAltogether 35 articles comprising 37 patients were included. Acute pancreatitis was the first presentation of COVID-19 in 43% of patients, concurrent with general or respiratory symptoms in 14% of patients or delayed after general or pulmonary symptoms by an average of 10 ± 5 d (range, 1 - 19 d) in 43% of patients. Serum amylase and lipase levels were elevated in 87% and 100% of patients. In 50% and 84%, amylase and lipase levels exceeded three-fold the upper normal limit. Pancreatic necrosis was reported in 6% of patients and in 12% of patients, the pancreas appeared normal. Three patients died.
conclusionsWe conclude that the bi-modal pattern of the onset of symptoms supports both the cytotoxic and the immune-related pathogenesis of the pancreatic injury. Acute pancreatitis may be the first symptom of COVID-19 infection. Necrosis of the pancreas is rare.
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