Evidence map›Paper›PMID 33989099›Full record

ArticleDrug metabolism reviews2021

Recent developments in

Jaydeep Yadav, Mehdi El Hassani, Jasleen Sodhi, Volker M Lauschke, Jessica H Hartman, Laura E Russell

Abstract read
In one paragraph

Article in Drug metabolism reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. A CYP3A7 metabolically competent human induced pluripotent stem cell-derived hepatocyte-like cell (hHLCDrug metabolism and disposition: the biological fate of chemicals · 2026
    Article
  5. Article
  6. Characterization and genome analyses of the novel phages targeting extraintestinal Escherichia coli clones ST131 and ST410.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. MultiplexedNucleic acid therapeutics · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jaydeep YadavDepartment of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Boston, MA, USA.
Mehdi El HassaniFaculty of Pharmacy, Université de Montréal, Montréal, Canada.
Jasleen SodhiDepartment of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA, USA.
Volker M LauschkeDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Jessica H HartmanDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Laura E RussellTheravance Biopharma US, Inc., South San Francisco, CA, USA.

Funding

The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Evan R Delgado · 2020 to 2026
$18.7M
Maximizing Opportunities for Research Excellence - Evaluation Training SupplementR25GM056847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, D'ANNE S., SELLO, JASON K · 1998 to 2023
$14.1M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Garth R Swanson · 2020 to 2026
$8.8M
Exercise, MANF, and Chemical-Induced NeurodegenerationR00ES029552 · NIEHS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HARTMAN, JESSICA HELENE · 2021 to 2023
$751k
NIDDK NIH HHS P30 DK123704NIEHS NIH HHS R00 ES029552NIGMS NIH HHS P20 GM130457NIGMS NIH HHS R25 GM056847
6 · The paper itself

Abstract

Improved pharmacokinetics/pharmacodynamics (PK/PD) prediction in the early stages of drug development is essential to inform lead optimization strategies and reduce attrition rates. Recently, there have been significant advancements in the development of new

Indexed as

Clearance predictionintrinsic clearancein-vitro in-vivo extrapolationin-vivo modelszebrafish

Identifiers

PMID33989099
PMCPMC8381685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.