Evidence map›Paper›PMID 33989040›Full record

ArticleEnvironmental health perspectives2021

Umbilical Cord Blood Metal Mixtures and Birth Size in Bangladeshi Children.

Mi-Sun Lee, Ki-Do Eum, Mostofa Golam, Quazi Quamruzzaman, Molly L Kile, Maitreyi Mazumdar, David C Christiani

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

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  11. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Mi-Sun LeeEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Ki-Do EumDepartment of Civil and Environmental Engineering, School of Engineering, Tufts University, Medford, Massachusetts, USA.
Mostofa GolamDhaka Community Hospital Trust, Dhaka, Bangladesh.
Quazi QuamruzzamanDhaka Community Hospital Trust, Dhaka, Bangladesh.
Molly L KileCollege of Public Health and Human Science, Oregon State University, Corvallis, Oregon, USA.
Maitreyi MazumdarEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
David C ChristianiEnvironmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Dhaka Community Hospital Trust · BDHarvard University · USBoston Children's Hospital · USOregon State University · USTufts University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Arsenic Exposure and Birth Outcomes in BangladeshR01ES015533 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHRISTIANI, DAVID C · 2007 to 2011
$2.1M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES015533
6 · The paper itself

Abstract

backgroundStudies have evaluated environmental exposure to toxic metals such as arsenic (As), cadmium (Cd), manganese (Mn), or lead (Pb) on birth size; however, information on potential effects of exposures to metal mixtures is limited.

objectivesWe assessed the association between metal mixtures (As, Cd, Mn, Pb) in umbilical cord blood and neonate size in Bangladeshi children.

methodsIn this birth cohort study, pregnant women who were

resultsData from 1,088 participants was assessed. We found a significant negative association between metal mixture and birth length and head circumference when all metal concentrations were above the 60th and 55th percentiles, respectively, compared with the median. An interquartile range (IQR) increase in log Cd concentration {log[Cd (in micrograms per deciliter)] DISCUSSION: Metal mixtures in cord blood were associated with reduced birth size in Bangladeshi children. Results from linear regression models adjusted and the BKMR mixtures analyses suggest adverse effects of Cd and Mn, as individual metal exposures, on birth size outcomes. https://doi.org/10.1289/EHP7502.

Indexed as

Body SizeFetal BloodMetalsPrenatal Exposure Delayed EffectsArsenicBangladeshBayes TheoremCohort StudiesFemaleHumansInfant, NewbornPregnancyArsenicMetals

Identifiers

PMID33989040
PMCPMC8121379
OpenAlexW3161605516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.