Evidence map›Paper›PMID 33988292›Full record

ArticleJournal of biomedical materials research. Part A2021

Intrinsic osteoinductivity of PCL-DA/PLLA semi-IPN shape memory polymer scaffolds.

Ahmad S Arabiyat, Michaela R Pfau, Melissa A Grunlan, Mariah S Hahn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  8. Shape Memory Polymer Scaffolds-Utility for In Vitro Osteogenesis of Canine Multipotent Stromal Cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ahmad S ArabiyatDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute (RPI), Troy, New York, USA.ORCID 0000-0001-8893-5385
Michaela R PfauDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.
Melissa A GrunlanDepartment of Biomedical Engineering, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-5428-0461
Mariah S HahnDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute (RPI), Troy, New York, USA.ORCID 0000-0001-8794-129X
Rensselaer Polytechnic Institute · USTexas A&M University · US

Funding

Bioactive, "Self-fitting" Shape Memory Polymer (SMP) Scaffolds to Treat Cranial Bone DefectsR01DE025886 · NIDCR · TEXAS ENGINEERING EXPERIMENT STATION · PI GRUNLAN, MELISSA · 2017 to 2020
$1.8M
A Self-Cleaning Membrane to Extend the Lifetime of an Implanted Glucose BiosensorR01DK095101 · NIDDK · TEXAS ENGINEERING EXPERIMENT STATION · PI GRUNLAN, MELISSA · 2012 to 2016
$1.6M
Shape Memory Polymer Scaffolds to Treat Bone Defects in Patients with Alzheimer's DiseaseR03AG067140 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI GRUNLAN, MELISSA, HAHN, MARIAH S · 2020 to 2021
$236k
NIA NIH HHS R03 AG067140NIDCR NIH HHS R01 DE025886NIDCR NIH HHS R01DE025886-03NIDDK NIH HHS R01 DK095101NIDDK NIH HHS R01DK095101-01A1
6 · The paper itself

Abstract

Engineering osteoinductive, self-fitting scaffolds offers a potential treatment modality to repair irregularly shaped craniomaxillofacial bone defects. Recently, we innovated on osteoinductive poly(ε-caprolactone)-diacrylate (PCL-DA) shape memory polymers (SMPs) to incorporate poly-L-lactic acid (PLLA) into the PCL-DA network, forming a semi-interpenetrating network (semi-IPN). Scaffolds formed from these PCL-DA/PLLA semi-IPNs display stiffnesses within the range of trabecular bone and accelerated degradation relative to scaffolds formed from slowly degrading PCL-DA SMPs. Herein, we demonstrate for the first time that PCL-DA/PLLA semi-IPN SMP scaffolds show increased intrinsic osteoinductivity relative to PCL-DA. We also confirm that application of a bioinspired polydopamine (PD) coating further improves the osteoinductive capacity of these PCL-DA/PLLA semi-IPN SMPs. In the absence of osteogenic supplements, protein level assessment of human mesenchymal stem cells (h-MSCs) cultured in PCL-DA/PLLA scaffolds revealed an increase in expression of osteogenic markers osterix, bone morphogenetic protein-4 (BMP-4), and collagen 1 alpha 1 (COL1A1), relative to PCL-DA scaffolds and osteogenic medium controls. Likewise, the expression of runt-related transcription factor 2 (RUNX2) and BMP-4 was elevated in the presence of PD-coating. In contrast, the chondrogenic and adipogenic responses associated with the scaffolds matched or were reduced relative to osteogenic medium controls, indicating that the scaffolds display intrinsic osteoinductivity.

Indexed as

OsteogenesisTissue EngineeringCaproatesHumansIndolesLactonesMesenchymal Stem CellsPolyestersPolymersSmart MaterialsTissue ScaffoldsCaproatescaprolactoneIndolesLactonespolydopaminePolyesterspoly(lactide)PolymersSmart Materialsbone marrow-derived mesenchymal stem cellscraniomaxillofacial defectsosteogenesispolydopaminepoly-L-lactic acidpoly(ε-caprolactone)shape memory polymers

Identifiers

PMID33988292
PMCPMC8736335
OpenAlexW3161276499

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.