Evidence map›Paper›PMID 33987811›Full record

ReviewFish physiology and biochemistry2021

Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research.

S Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M Rajesh, V J Rejish Kumar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Fish physiology and biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Genetic Architecture of Growth Traits in Turbot (International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A NovelAquaculture nutrition · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Enhancement of Thermal Tolerance and Growth Performances of Asian Seabass (Animals : an open access journal from MDPI · 2024
    Article
  16. Article
  17. Article
  18. Investigating the Mechanism of Low-Salinity Environmental Adaptation inAnimals : an open access journal from MDPI · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

S ChandhiniCentre of Excellence in Sustainable Aquaculture and Aquatic Animal Health Management (CAAHM), Department of Aquaculture, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, 682506, Kerala, India.
Bushra TrumbooCentre of Excellence in Sustainable Aquaculture and Aquatic Animal Health Management (CAAHM), Department of Aquaculture, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, 682506, Kerala, India.
Seena JoseNational Centre for Aquatic Animal Health, Cochin University of Science and Technology, Kochi, 682016, Kerala, India.
Tincy VargheseFish Physiology and Biochemistry Division, ICAR-Central Institute of Fisheries Education, Off-Yari Road, Versova, Andheri (W), Mumbai, 400061, India.
M RajeshICAR-Directorate of Coldwater Fisheries Research, Anusandhan Bhawan, Bhimtal, 263136, Uttarakhand, India.
V J Rejish KumarCentre of Excellence in Sustainable Aquaculture and Aquatic Animal Health Management (CAAHM), Department of Aquaculture, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, 682506, Kerala, India. rejishkumar@gmail.com.ORCID http://orcid.org/0000-0001-7780-614X
Kerala University of Fisheries and Ocean Studies · INCentral Institute of Fisheries Education · INCochin University of Science and Technology · INDirectorate of Coldwater Fisheries Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The insulin-like growth factor signalling system comprises insulin-like growth factors, insulin-like growth factor receptors and insulin-like growth factor-binding proteins. Along with the growth hormones, insulin-like growth factor signalling is very pivotal in the growth and development of all vertebrates. In fishes, insulin-like growth factors play an important role in osmoregulation, besides the neuroendocrine regulation of growth. Insulin-like growth factor concentration in plasma can assess the growth in fishes and shellfishes and therefore widely applied in nutritional research as an indicator to evaluate the performance of selected nutrients. The present review summarizes the role of insulin-like growth factor signalling in fishes and shellfishes, its significance in aquaculture and in evaluating growth, reproduction and development, and discusses the utility of this system as biomarkers for early indication of growth in aquaculture.

Indexed as

ShellfishAnimalsBiomarkersFishesSignal TransductionSomatomedinsBiomarkersSomatomedinsIGF-binding proteinIGF in aquacultureIGF receptorIGF signallingIGF signalling in fishInsulin-like growth factor

Identifiers

PMID33987811
OpenAlexW3161243187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.