ArticleAmerican journal of epidemiology2021
Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health Across the Life Span.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- "We adjusted for race": now what? A systematic review of utilization and reporting of race in American Journal of Epidemiology and Epidemiology, 2020-2021.Epidemiologic reviews · 2023Pooled it
- Associations of county-level school expenditure around time of birth and cardiovascular health in young adulthood.American journal of preventive cardiology · 2026Article
- Income Volatility During Early to Mid-adulthood and 10-year Memory Decline in a Longitudinal Synthetic Cohort.Epidemiology (Cambridge, Mass.) · 2026Article
- Synthetic artificial intelligence in cardiology: from generative models to clinical applications.European heart journal open · 2026Review
- Obesity from Childhood to Mid-adulthood in the United States: A Synthetic Cohort Approach to Measuring Health Trajectories.Epidemiology (Cambridge, Mass.) · 2026Article
- An Introduction to Longitudinal Synthetic Cohorts for Studying the Life Course Drivers of Health Outcomes and Inequalities in Older Age.Current epidemiology reports · 2025Article
- Health economic evaluation of trans-tibial prosthetic suspension systems: a protocol for a pilot using an observational study and synthetic cohort.Cost effectiveness and resource allocation : C/E · 2025Article
- Overcoming Data Gaps in Life Course Epidemiology by Matching Across Cohorts.Epidemiology (Cambridge, Mass.) · 2024Article
- Aging, Race, and Health Disparities: Recommendations From the Research Centers Collaborative Network.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Five-Year Cumulative Cardiovascular Health and Clinical Events in Patients With Chronic Kidney Disease: The CRIC Study.Journal of the American Heart Association · 2024Article
- Longitudinal clustering of Life's Essential 8 health metrics: application of a novel unsupervised learning method in the CARDIA study.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Translating RDoC to Real-World Impact in Developmental Psychopathology: A Neurodevelopmental Framework for Application of Mental Health Risk Calculators.Development and psychopathology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
We developed and validated a synthetic cohort approach to examine numbers of cardiovascular risk factors (CRFs) and adverse clinical events, including incident cardiovascular disease and all-cause mortality, across the life span from ages 20 years to 90 years. The current analysis included 40,875 participants from 7 large, population-based longitudinal epidemiologic studies (1948-2016). On the basis of a joint multilevel imputation model, we multiply imputed each participant's life-span numbers of CRFs and events using available records. To validate the imputed values, we partially removed the observed data and then compared the imputed and observed values. The complete life-span synthetic data set reflected the original observed data trends well. In our validation sample, the distributions of imputed CRFs and events were close to the observed distributions but with less variability. Bland-Altman plots indicated that there was a slightly negative trend in general, and the agreement bias was relatively small for the continuous CRFs. The hypothetical linear regression model suggested that the relationships between the CRFs and events were preserved in the imputed data set. This approach generated valid estimates of CRFs and events across the life span for African-American and White participants. The synthetic cohort may be sufficiently accurate to be useful in assessing the origins and timing of accumulating cardiovascular risk that can inform efforts to avoid cardiovascular disease development.
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