ArticleCerebral cortex (New York, N.Y. : 1991)2021
A Distinct Population of L6 Neurons in Mouse V1 Mediate Cross-Callosal Communication.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- FACED 2.0 enables large-scale voltage and calcium imaging in vivo.Nature methods · 2026Article
- OPTRACE: Optical Imaging-Guided Transplantation and Tracking of Cells in the Mouse Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Inter- and intrahemispheric sources of vestibular signals to V1.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Near-random connections support top-down feature-based attentional modulations in early sensory cortex.PLoS computational biology · 2025Article
- Reciprocal interaction between cortical SST and PV interneurons in top-down regulation of retinothalamic refinement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback.eLife · 2025Article
- A primary sensory cortical interareal feedforward inhibitory circuit for tacto-visual integration.Nature communications · 2024Article
- 3D printing-based frugal manufacturing of glass pipettes for minimally invasive delivery of therapeutics to the brain.Neuroprotection (Chichester, England) · 2023Article
- Experience-dependent functional plasticity and visual response selectivity of surviving subplate neurons in the mouse visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- The functional characterization of callosal connections.Progress in neurobiology · 2022Review
- Analysis of segmentation ontology reveals the similarities and differences in connectivity onto L2/3 neurons in mouse V1.Scientific reports · 2021Article
- Auditory Corticothalamic Neurons Are Recruited by Motor Preparatory Inputs.Current biology : CB · 2021Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Through the corpus callosum, interhemispheric communication is mediated by callosal projection (CP) neurons. Using retrograde labeling, we identified a population of layer 6 (L6) excitatory neurons as the main conveyer of transcallosal information in the monocular zone of the mouse primary visual cortex (V1). Distinct from L6 corticothalamic (CT) population, V1 L6 CP neurons contribute to an extensive reciprocal network across multiple sensory cortices over two hemispheres. Receiving both local and long-range cortical inputs, they encode orientation, direction, and receptive field information, while are also highly spontaneous active. The spontaneous activity of L6 CP neurons exhibits complex relationships with brain states and stimulus presentation, distinct from the spontaneous activity patterns of the CT population. The anatomical and functional properties of these L6 CP neurons enable them to broadcast visual and nonvisual information across two hemispheres, and thus may play a role in regulating and coordinating brain-wide activity events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.