Evidence map›Paper›PMID 33987620›Full record

ArticleNetwork and systems medicine2020

Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules.

Lucas A Gillenwater, Katherine A Pratte, Brian D Hobbs, Michael H Cho, Yonghua Zhuang, Eitan Halper-Stromberg, Charmion Cruickshank-Quinn, Nichole Reisdorph, Irina Petrache, Wassim W Labaki and 9 more

Open access · diamondAbstract read
In one paragraph

Article in Network and systems medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Metabolomic profiling reveals distinct and shared biology in COPD and IPF.Metabolomics : Official journal of the Metabolomic Society · 2026
    Article
  3. Article
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  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Air pollution, metabolites and respiratory health across the life-course.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  15. Article
  16. Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 1 country.

Lucas A GillenwaterNational Jewish Health, Denver, Colorado, USA.
Katherine A PratteNational Jewish Health, Denver, Colorado, USA.
Brian D HobbsChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Yonghua ZhuangDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Eitan Halper-StrombergDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Charmion Cruickshank-QuinnAgilent Technologies, Santa Clara, California, USA.
Nichole ReisdorphSkaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Irina PetracheNational Jewish Health, Denver, Colorado, USA.
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Wanda K O'NealLung Institute/Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Victor E OrtegaDepartment of Internal Medicine, Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Dean P JonesClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory School of Medicine, Atlanta, Georgia, USA.
Karan UppalClinical Biomarkers Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory School of Medicine, Atlanta, Georgia, USA.
Sean JacobsonNational Jewish Health, Denver, Colorado, USA.
Gregory MichelottiMetabolon, Inc., Morrisville, North Carolina, USA.
Christine H WendtDepartment of Medicine, University of Minnesota and the VAMC, Minneapolis, Minnesota, USA.
Katerina J KechrisDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Russell P BowlerNational Jewish Health, Denver, Colorado, USA.
National Jewish Health · USBrigham and Women's Hospital · USColorado School of Public Health · USPulmonary and Allergy Associates · USAgilent Technologies (United States) · USJohns Hopkins University · USMetabolon (United States) · USMinneapolis VA Medical Center · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USWake Forest University · US

Funding

Ceramide-induced Lung Destruction in EmphysemaR01HL077328 · NHLBI · NATIONAL JEWISH HEALTH · PI PETRACHE, IRINA · 2006 to 2024
$8.0M
Addressing Sparsity in Metabolomics Data AnalysisU01CA235488 · NCI · UNIVERSITY OF COLORADO DENVER · PI GHOSH, DEBASHIS, KECHRIS-MAYS, KATHERINA · 2018 to 2021
$1.8M
Multi-omic Subtyping of Chronic Obstructive Pulmonary DiseaseK08HL136928 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HOBBS, BRIAN DANIEL · 2017 to 2021
$864k
NCI NIH HHS U01 CA235488NHLBI NIH HHS K08 HL136928NHLBI NIH HHS R01 HL077328
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chronic obstructive pulmonary diseaseintegrated omicsmetabolomic quantitative trait analysismetabolomicsnetwork analysis

Identifiers

PMID33987620
PMCPMC8109053
OpenAlexW3119573237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.