Evidence map›Paper›PMID 33987360›Full record

ArticleAnnals of translational medicine2021

Binding of microRNA-135a (miR-135a) to homeobox protein A10 (

Xi Luo, Renxiang Yang, Yun Bai, Lei Li, Na Lin, Lan Sun, Jianjun Liu, Ze Wu

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Role of HOXA10 in pathologies of the endometrium.Reviews in endocrine & metabolic disorders · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xi LuoFaculty of Life science and Technology, Kunming University of Science and Technology, Kunming, China.
Renxiang YangMedical School, Kunming University of Science and Technology, Kunming, China.
Yun BaiDepartment of Reproductive Medicine, the First People's Hospital of Yunnan Province, Kunming, China.
Lei LiDepartment of Reproductive Medicine, the First People's Hospital of Yunnan Province, Kunming, China.
Na LinDepartment of Reproductive Medicine, the First People's Hospital of Yunnan Province, Kunming, China.
Lan SunMedical School, Kunming University of Science and Technology, Kunming, China.
Jianjun LiuYunnan Key Laboratory of Stem Cell and Regenerative Medicine, Research Center of Biomedical Engineering, Kunming Medical University, Kunming, China.
Ze WuDepartment of Reproductive Medicine, the First People's Hospital of Yunnan Province, Kunming, China.
Kunming University of Science and Technology · CNFirst People's Hospital of Yunnan Province · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with elevated circulating progesterone concentrations on the day of the human chorionic gonadotropin (hCG) trigger had relatively low implantation rates during assisted reproductive treatments. In this study, we assess the hypothesis that different concentrations of progesterone regulate the expression of homeobox protein A10 (HOXA10) and its downstream genes through miRNA-135a.

methodsMicroRNA-135a (

resultsHigh progesterone levels promoted miR-135a expression in vivo, and miR-135a bound to the 3'-untranslated region (3'-UTR) of

conclusions

Indexed as

beta3-integrin (ITGβ3)Empty spiracles homeobox-2 (EMX2)homeobox protein A10 (HOXA10)implantation ratemicroRNA-135a (miR-135a)progesterone elevation

Identifiers

PMID33987360
PMCPMC8106024
OpenAlexW3159514868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.