ArticlePeerJ2021
Dysregulation of miR-381-3p and miR-23b-3p in skeletal muscle could be a possible estimator of early post-mortem interval in rats.
Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- microRNAs as New Biomolecular Markers to Estimate Time since Death: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- A small RNA, microRNA as a potential biomolecular marker to estimate post mortem interval in forensic science: a systematic review.International journal of legal medicine · 2023Pooled it
- Transcriptomic analysis at 48 h postmortem: a proof of concept for the identification of biomarkers to estimate time since death.Molecular biology reports · 2025Article
- Detection of miR-133a-5p Using a Molecular Beacon Probe for Investigating Postmortem Intervals.Non-coding RNA · 2024Article
- The potential of using non-coding RNAs in forensic science applications.Forensic sciences research · 2023Review
- Review of the current and potential use of biological and molecular methods for the estimation of the postmortem interval in animals and humans.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2023Review
- Article
- MiR-29a Family as a Key Regulator of Skeletal Muscle Dysplasia in a Porcine Model of Intrauterine Growth Retardation.Biomolecules · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe post-mortem interval (PMI) is the time elapsed since the dead of an individual until the body is found, which is relevant for forensic purposes. The miRNAs regulate the expression of some genes; and due to their small size, they can better support degradation, which makes them suitable for forensic analysis. In the present work, we evaluated the gene expression of miR-381-3p, miR-23b-3p, and miR-144-3p in skeletal muscle in a murine model at the early PMI.
methodsWe designed a rat model to evaluate the early PMI under controlled conditions. This model consisted in 25 rats divided into five groups of rats, that correspond to the 0, 3, 6, 12 and 24 hours of PMI. The 0 h-PMI was considered as the control group. Muscle samples were taken from each rat to analyze the expression of miR-381-3p, miR-23b-3p, and miR-144-3p by quantitative RT-PCR. The gene expression of each miRNA was expressed as
resultsAn upregulation of miR-381-3p was found at 24 h-PMI compared with the control group of 0 h-PMI and (FC = 1.02 vs. FC = 1.96; DISCUSSION: The present results suggest that miR-23b-3p and miR-381-3p participate at the early PMI, probably regulating the expression of some genes related to the autolysis process as
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