Evidence map›Paper›PMID 33986810›Full record

ArticleStem cells international2021

Surface Modification with NGF-Loaded Chitosan/Heparin Nanoparticles for Improving Biocompatibility of Cardiovascular Stent.

Haixin Song, Tao Wu, Xiaotian Yang, Yangzheng Li, Ye Ye, Bo Li, Tao Liu, Shihui Liu, Jianhua Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Nano-embedded medical devices and delivery systems in interventional radiology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haixin SongDepartment of Rehabilitation, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000 Zhejiang Province, China.ORCID https://orcid.org/0000-0002-7926-4855
Tao WuDepartment of Rehabilitation, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000 Zhejiang Province, China.ORCID https://orcid.org/0000-0002-8799-7178
Xiaotian YangDepartment of Rehabilitation, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000 Zhejiang Province, China.
Yangzheng LiDepartment of Rehabilitation, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000 Zhejiang Province, China.
Ye YeDepartment of Rehabilitation, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000 Zhejiang Province, China.
Bo LiDepartment of Rehabilitation, Tongde Hospital of Zhejiang Province, Hangzhou, 310000 Zhejiang Province, China.ORCID https://orcid.org/0000-0001-7988-0247
Tao LiuMedical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006 Guangdong Province, China.
Shihui LiuMedical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, 510006 Guangdong Province, China.ORCID https://orcid.org/0000-0003-4311-5740
Jianhua LiDepartment of Rehabilitation, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000 Zhejiang Province, China.ORCID https://orcid.org/0000-0001-5783-5090

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Late thrombosis and restenosis remain major challenges to the safety of drug-eluting stents. Biofunctional modification to endow the surface with selective anticoagulation and promote endothelium regeneration has become a hotpot recently. In this study, chitosan and heparin were found to form three-dimensional nanoparticles by spontaneous electrostatic interaction. Based on the specific binding properties between heparin and nerve growth factor (NGF), a new type of NGF-loaded heparin/chitosan nanoparticles was constructed for surface modification. The results of material characterization show that the nanoparticles are successfully immobilized on the surface of the material. In vitro blood compatibility and endothelial cell compatibility assay showed that the modified surface could selectively inhibit platelet adhesion and smooth muscle cell overproliferation, while accelerating endothelialization via promoting endothelial cell proliferation and enhancing endothelial progenitor cell mobilization.

Identifiers

PMID33986810
PMCPMC8093045

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.