Evidence map›Paper›PMID 33986741›Full record

ArticleFrontiers in immunology2021

Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1.

Matej Fabisik, Jolana Tureckova, Nataliia Pavliuchenko, Jarmila Kralova, Jana Balounova, Kristina Vicikova, Tereza Skopcova, Frantisek Spoutil, Jana Pokorna, Pavla Angelisova and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  9. Single-cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  11. DNA Methylation in Alzheimer's Disease.Current topics in behavioral neurosciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Matej FabisikLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Jolana TureckovaLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.
Nataliia PavliuchenkoLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Jarmila KralovaLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Jana BalounovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.
Kristina VicikovaCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.
Tereza SkopcovaLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Frantisek SpoutilCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.
Jana PokornaLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Pavla AngelisovaLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Bernard MalissenCentre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, Marseille, France.
Jan ProchazkaLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.
Radislav SedlacekLaboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czechia.
Tomas BrdickaLaboratory of Leukocyte Signalling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Czech Academy of Sciences, Institute of Molecular Genetics · CZCentre d'Immunophénomique

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative regulatory function in leukocyte signaling. It was also shown to be involved in cytoskeleton regulation and generation of tunneling nanotubes.

Indexed as

Gene Expression RegulationSignal TransductionAnimalsBiomarkersColitisDendritic CellsDisease Models, AnimalDisease SusceptibilityGenotypeHumansIntracellular Signaling Peptides and ProteinsLeukocytesLipopolysaccharidesMacrophagesMembrane ProteinsMiceBiomarkersIntracellular Signaling Peptides and ProteinsLipopolysaccharidesLST1 protein, humanMembrane Proteinscolitisinflammationinflammatory bowel diseaseLST1myeloid cells

Identifiers

PMID33986741
PMCPMC8111073
OpenAlexW3158129026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.