Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.

Andreas Neuhof, Yuemin Tian, Anna Reska, Björn H Falkenburger, Stefan Gründer

Open access · goldAbstract read

In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

0.6field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

Gap Junctional Communication Required for the Establishment of Long-Term Robust CaCells · 2025
Article
Roles of SNORD115 and SNORD116 ncRNA clusters during neuronal differentiation.Nature communications · 2024
Article
Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link?Pflugers Archiv : European journal of physiology · 2024
Review
Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects.Toxins · 2022
Review
Retinoic Acid-Differentiated Neuroblastoma SH-SY5Y Is an Accessible In Vitro Model to Study Native Human Acid-Sensing Ion Channels 1a (ASIC1a).Biology · 2022
Article
Activated Endolysosomal Cation Channel TRPML1 Facilitates Maturation of α-Synuclein-Containing Autophagosomes.Frontiers in cellular neuroscience · 2022
Article
Commentary: Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.Frontiers in cellular neuroscience · 2021
Article

4 · The record

Corrections and comments

Commented on by
Commentary: Large Acid-Evoked Currents, Mediated by ASIC1a, Accompany Differentiation in Human Dopaminergic Neurons.2021

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andreas NeuhofDepartment of Neurology, Institute of Physiology, RWTH Aachen University, Aachen, Germany.

Yuemin TianDepartment of Neurology, Institute of Physiology, RWTH Aachen University, Aachen, Germany.

Anna ReskaDepartment of Neurology, Institute of Physiology, RWTH Aachen University, Aachen, Germany.

Björn H FalkenburgerDepartment of Neurology, RWTH Aachen University, Aachen, Germany.

Stefan GründerDepartment of Neurology, Institute of Physiology, RWTH Aachen University, Aachen, Germany.

RWTH Aachen University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acid-sensing ion channels (ASICs) are proton-gated Na

Indexed as

acid-sensing ion channelCa2+ imagingdopaminergic neuron differentiationLUHMES cellsmidbrainneuronal differentiation

Identifiers

PMID33986647

DOI10.3389/fncel.2021.668008

PMCPMC8110905

OpenAlexW3158341758

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.