Evidence map›Paper›PMID 33986645›Full record

ArticleFrontiers in cellular neuroscience2021

Visual Deprivation Retards the Maturation of Dendritic Fields and Receptive Fields of Mouse Retinal Ganglion Cells.

Hui Chen, Hong-Ping Xu, Ping Wang, Ning Tian

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Tunable dual-AAV sparse labeling of PVFrontiers in neural circuits · 2025
    Article
  5. Review
  6. Article
  7. Receptive Field Sizes ofInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hui ChenDepartment of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United States.
Hong-Ping XuDepartment of Neurobiology, Yale University School of Medicine, New Haven, CT, United States.
Ping WangDepartment of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United States.
Ning TianDepartment of Ophthalmology and Visual Science, University of Utah School of Medicine, Salt Lake City, UT, United States.
University of Utah · USYale University · US

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Behrad Noudoost · 2005 to 2026
$14.6M
DEVELOPMENT OF SYNAPTIC PATHWAYS IN RETINAR01EY012345 · NEI · YALE UNIVERSITY · PI TIAN, NING · 1999 to 2015
$5.1M
Mechanisms underlying CD3ζ guided assembly of retinal circuitsR01EY031699 · NEI · UNIVERSITY OF UTAH · PI TIAN, NING · 2020 to 2023
$1.5M
Immune responses in traumatic RGC deathI01BX002412 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI TIAN, NING · 2016 to 2024
–
BLRD VA I01 BX002412NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY012345NEI NIH HHS R01 EY031699
6 · The paper itself

Abstract

It was well documented that both the size of the dendritic field and receptive field of retinal ganglion cells (RGCs) are developmentally regulated in the mammalian retina, and visual stimulation is required for the maturation of the dendritic and receptive fields of mouse RGCs. However, it is not clear whether the developmental changes of the RGC receptive field correlate with the dendritic field and whether visual stimulation regulates the maturation of the dendritic field and receptive field of RGCs in a correlated manner. The present work demonstrated that both the dendritic and receptive fields of RGCs continuously develop after eye opening. However, the correlation between the developmental changes in the receptive field size and the dendritic field varies among different RGC types. These results suggest a continuous change of synaptic converging of RGC synaptic inputs in an RGC type-dependent manner. Besides, light deprivation impairs both the development of dendritic and receptive fields.

Indexed as

activity-dependent plasticitydendritic morphologydevelopmentlight deprivationreceptive field (RF)retinal ganglion cell

Identifiers

PMID33986645
PMCPMC8111083
OpenAlexW3158671105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.