ArticleDegenerative neurological and neuromuscular disease2021
Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer's Disease.
Article in Degenerative neurological and neuromuscular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Alzheimer's Disease Pathogenic Mechanisms: Linking Redox Homeostasis and Mitochondria-Associated Metabolic Pathways Through Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2).Antioxidants (Basel, Switzerland) · 2025Review
- Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice.Foods (Basel, Switzerland) · 2025Article
- Cognitive and anti-inflammatory effects ofFrontiers in neuroscience · 2025Article
- Melatonin: A potential nighttime guardian against Alzheimer's.Molecular psychiatry · 2025Review
- Food Functional Factors in Alzheimer's Disease Intervention: Current Research Progress.Nutrients · 2024Review
- Protective Activity of Melatonin Combinations and Melatonin-Based Hybrid Molecules in Neurodegenerative Diseases.Journal of pineal research · 2024Review
- Protective Effect of the Novel Melatonin Analogue Containing Donepezil Fragment on Memory Impairment via MT/ERK/CREB Signaling in the Hippocampus in a Rat Model of Pinealectomy and Subsequent AβInternational journal of molecular sciences · 2024Article
- Melatonin in Alzheimer's Disease: Literature Review and Therapeutic Trials.Journal of Alzheimer's disease : JAD · 2024Review
- Exploring the potential use of melatonin as a modulator of tramadol-induced rewarding effects in rats.Frontiers in pharmacology · 2024Article
- Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis.Frontiers in molecular neuroscience · 2024Article
- [Study on effects of 40 Hz light flicker stimulation on spatial working memory in rats and its neural mechanism].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model.IBRO neuroscience reports · 2023Article
- Protective role of resveratrol against VCM-induced hepatotoxicity in male wistar rats.Frontiers in pharmacology · 2023Article
- Melatonin: A Neurotrophic Factor?Molecules (Basel, Switzerland) · 2022Review
- Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat.International journal of molecular sciences · 2022Article
- Deciphering the Link Between ERFrontiers in aging neuroscience · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlzheimer's disease (AD) is a neurodegenerative disease that has become a leading cause of death in recent years. Impairments in spatial learning and memory are an important clinical feature of AD. Melatonin (MLT), the main product secreted by the pineal gland, showed multiple antioxidant, anti-inflammatory, and neuroprotective properties. PURPOSE: The present study aimed to explore the possible prophylactic effects of MLT against spatial memory deficits in a sporadic mouse model of AD induced by D-galactose and aluminium chloride (AlCl
methodsFour groups of mice (
resultsWe found that MLT improved spatial memory in the sporadic AD mice. MLT ameliorated
conclusionMLT could have a substantial potential to alleviate memory impairment in sporadic AD if introduced at early stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.