Evidence map›Paper›PMID 33986610›Full record

ArticlePharmacogenomics and personalized medicine2021

Nan Guo, Peng Qu, Hao Li, Liuli Liu, Hao Jin, Renqi Liu, Zhen Zhang, Xuan Zhang, Yingchun Li, Xiaobo Lu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmacogenomics and personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Polymorphisms of DNA Repair Genes in Thyroid Cancer.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nan GuoDepartment of Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, People's Republic of China.
Peng QuDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Hao LiDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Liuli LiuDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Hao JinJin Zhou Center for Disease Control and Prevention, Jinzhou, People's Republic of China.
Renqi LiuJin Zhou Center for Disease Control and Prevention, Jinzhou, People's Republic of China.
Zhen ZhangJin Zhou Center for Disease Control and Prevention, Jinzhou, People's Republic of China.
Xuan ZhangDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, People's Republic of China.
Yingchun LiDepartment of Central Laboratory, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, People's Republic of China.
Xiaobo LuDepartment of Toxicology, School of Public Health, China Medical University, Shenyang, People's Republic of China.ORCID 0000-0002-3136-9439
Yuejiao ZhaoDepartment of Head and Neck Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, People's Republic of China.
China Medical University · CNChinese Center For Disease Control and Prevention · CNLiaoning Cancer Hospital & Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the associations of polymorphisms in the following DNA double-strand break repair (DSBR) genes with papillary thyroid carcinoma (PTC) risk (including MATERIALS AND

methodsA matched case-control study was implemented to examine associations between PTC risk and the above polymorphisms. Subsequently, we evaluated the effects of the potential PTC susceptibility-related variant rs15869 on BRCA2 mRNA secondary structure and BRCA2 expression through bioinformatics analysis and experiment validation. Additionally, luciferase assay was used to identify whether rs15869 polymorphism can substantially affect the binding of hsa-miR-1178-3p to

results

conclusion

Indexed as

BRCA2DNA double-strand break repairhsa-miR-1178-3ppapillary thyroid carcinomars15869 polymorphism

Identifiers

PMID33986610
PMCPMC8112253
OpenAlexW3159657317

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.