ArticleNature nanotechnology2021
Cellular binding, uptake and biotransformation of silver nanoparticles in human T lymphocytes.
Article in Nature nanotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 95 citations in OpenAlex.
- New approach methodologies for next-generation risk assessment of nanomaterials and nano-enabled products.Nano convergence · 2026Review
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- Comparative impact of polystyrene, rice bag-derived high-density polyethylene nanoparticles, and polystyrene-silver nanoparticle interactions in a 28-day in vivo study in male and female Wistar rats.Scientific reports · 2026Article
- Investigation of molecular mechanisms in silver nanoparticle-induced cytotoxicity from gene to metabolite level.Scientific reports · 2025Article
- Genetic modulation of rare earth nanoparticle biotransformation shapes biological outcomes.Nature communications · 2025Article
- Silver Nanoparticles Prepared Using Magnolia officinalis Are an Effective Antimicrobial Agent on Candida albicans, Escherichia coli, and Staphylococcus aureus.Probiotics and antimicrobial proteins · 2025Article
- Tumor-Homing Phage Nanofibers for Nanozyme-Enhanced Targeted Breast Cancer Therapy.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Green Synthesis of Silver Nanoparticles with Roasted Green Tea: Applications in Alginate-Gelatin Hydrogels for Bone Regeneration.Gels (Basel, Switzerland) · 2024Article
- Metal-detection based techniques and their applications in metallobiology.Chemical science · 2024Review
- Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cell-Surface Binding of DNA Nanostructures for Enhanced Intracellular and Intranuclear Delivery.ACS applied materials & interfaces · 2024Article
- Biochemical transformations of inorganic nanomedicines in buffers, cell cultures and organisms.Nanoscale · 2023Review
- Ag nanocomposite hydrogels with immune and regenerative microenvironment regulation promote scarless healing of infected wounds.Journal of nanobiotechnology · 2023Article
- High-Throughput Single-Cell Analysis of Nanoparticle-Cell Interactions.Trends in analytical chemistry : TRAC · 2023Article
- Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system.Science advances · 2023Article
- Effect of Size, Shape and Surface Functionalization on the Antibacterial Activity of Silver Nanoparticles.Journal of functional biomaterials · 2023Review
- Zn(II) to Ag(I) Swap in Rad50 Zinc Hook Domain Leads to Interprotein Complex Disruption through the Formation of Highly Stable AgInorganic chemistry · 2023Article
- The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design.Nanomaterials (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our knowledge of uptake, toxicity and detoxification mechanisms as related to nanoparticles' (NPs') characteristics remains incomplete. Here we combine the analytical power of three advanced techniques to study the cellular binding and uptake and the intracellular transformation of silver nanoparticles (AgNPs): single-particle inductively coupled mass spectrometry, mass cytometry and synchrotron X-ray absorption spectrometry. Our results show that although intracellular and extracellularly bound AgNPs undergo major transformation depending on their primary size and surface coating, intracellular Ag in 24 h AgNP-exposed human lymphocytes exists in nanoparticulate form. Biotransformation of AgNPs is dominated by sulfidation, which can be viewed as one of the cellular detoxification pathways for Ag. These results also show that the toxicity of AgNPs is primarily driven by internalized Ag. In fact, when toxicity thresholds are expressed as the intracellular mass of Ag per cell, differences in toxicity between NPs of different coatings and sizes are minimized. The analytical approach developed here has broad applicability in different systems where the aim is to understand and quantify cell-NP interactions and biotransformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.