Evidence map›Paper›PMID 33986494›Full record

ArticleEuropean journal of clinical nutrition2022

Vitamin D status in Armenian women: a stratified cross-sectional cluster analysis.

Nicholas Hutchings, Varta Babalyan, Annemieke C Heijboer, Sisak Baghdasaryan, Mushegh Qefoyan, Arus Ivanyan, Mariëtte T Ackermans, Anna Maria Formenti, Olga Lesnyak, Andrea Giustina and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Trial
  2. Reducing early pregnancy loss with vitamin DJournal of clinical biochemistry and nutrition · 2025
    Article
  3. Article
  4. Proceedings of the 2023 Santa Fe Bone Symposium: Progress and Controversies in the Management of Patients with Skeletal Diseases.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Nicholas HutchingsSchool of Medicine, University of California, Irvine, CA, USA. nicholas.hutchings@columbia.edu.ORCID http://orcid.org/0000-0001-9964-142X
Varta BabalyanOsteoporosis Center of Armenia, Yerevan, Armenia.
Annemieke C HeijboerEndocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Vrije Universiteit Amsterdam & University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6712-9955
Sisak BaghdasaryanOsteoporosis Center of Armenia, Yerevan, Armenia.
Mushegh QefoyanOsteoporosis Center of Armenia, Yerevan, Armenia.
Arus IvanyanYerevan State Medical University, Yerevan, Armenia.
Mariëtte T AckermansEndocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, Vrije Universiteit Amsterdam & University of Amsterdam, Amsterdam, The Netherlands.
Anna Maria FormentiInstitute of Endocrine and Metabolic Sciences, San Raffaele, IRCCS Hospital, Vita-Salute University, Milano, Italy.
Olga LesnyakNorth West State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.
Andrea GiustinaInstitute of Endocrine and Metabolic Sciences, San Raffaele, IRCCS Hospital, Vita-Salute University, Milano, Italy.
John P BilezikianCollege of Physicians and Surgeons, Columbia University, New York, NY, USA.
Amsterdam University Medical Centers · NLVita-Salute San Raffaele University · ITColumbia University · USNorth-Western State Medical University named after I.I. Mechnikov · RUUniversity of California, Irvine · USYerevan State Medical University · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D plays a critical role in skeletal development and maintenance, thus sufficiency is an important goal for public health programs. Given the absence of foods fortified in vitamin D in Armenia, we hypothesized that vitamin D insufficiency would be widespread.

methodsWe conducted a random modified cluster model survey of vitamin D status of women in the country. We measured 25-hydroxyvitamin D [25(OH)D] by liquid chromatography mass spectrometry in dried blood spot samples and utilized a questionnaire to assess lifestyle factors.

resultsIn summer, we sampled 1206 participants from 40 communities in Armenia. Mean 25-OH D level among women aged 18-24 was 20 ± 8 ng/mL; aged 25-64 was 21 ± 7 ng/mL; and >65 was 18 ± 8 ng/mL. The country-wide mean of the entire female population was 20 ± 8 ng/mL. A majority (>54%) had 25-OH D levels <20 ng/mL with nearly 13% having 25-OH D levels <12 ng/mL. Participants who reported calcium, vitamin D, or multivitamin supplementation had higher levels of 25-OH D (p values 0.004, 0.0002, and 0.03 respectively) as did pre- vs. postmenopausal women (p = 0.01), pregnant vs. nonpregnant women (p = <0.0001), and women who had experienced a sunburn in the past year (p = 0.004).

conclusionIn Armenia, there is a high prevalence of vitamin D insufficiency. This information provides data that can be used to inform public health directives to address this pervasive threat to optimal health.

Indexed as

Vitamin D DeficiencyAdolescentAdultArmeniaCluster AnalysisCross-Sectional StudiesFemaleHumansMiddle AgedPregnancyPrevalenceVitamin DYoung AdultVitamin D

Identifiers

PMID33986494
PMCPMC8821010
OpenAlexW3161955214

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.