ArticleNature communications2021
Antigen-driven EGR2 expression is required for exhausted CD8
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
What it found
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Who cites it
46 citing papers in PubMed, 55 citations in OpenAlex.
- Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.Leukemia · 2026Article
- Candidate MicroRNA Regulatory Axes in Melanoma CD8+ T Cell Exhaustion: A Network-Based In Silico Stratification.Cureus · 2026Article
- Tumor-derived stearic acid induces macrophage Egr2 signaling to suppress anti-tumor immunity in breast cancer.bioRxiv : the preprint server for biology · 2026Article
- SC-framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets.iScience · 2026Article
- Identification of key genes associated with T cell exhaustion in HIV infection based on transcriptomic data.Virology journal · 2026Article
- The atypical IκB factor IκBδ enhances CD8 T cell accumulation and effector functions in solid tumors.bioRxiv : the preprint server for biology · 2026Article
- Identification of Pancreatic Ductal Adenocarcinoma Extracellular Matrix Signatures from In-Depth Proteomic Profiling that Correlate with Lymphocyte Infiltration.Cancer research communications · 2026Article
- Article
- Transcription factor collaboration enables precise T cell state engineering.bioRxiv : the preprint server for biology · 2026Article
- A post-translational regulatory map of chronic antigen-driven human T cell dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Flt3L-Derived Antigen-Presenting Cell Transfer in Neonatal NOD Mice Reduces the Incidence of Type 1 Diabetes.Diabetes · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Partially-functional exhausted CD8+ T cells can contribute to short-term viral suppression: a computational prediction for children with perinatal HIV.bioRxiv : the preprint server for biology · 2025Article
- Enhancing the potency of CAR-T cells against solid tumors through transcription factor engineering.JCI insight · 2025Review
- Multifaceted regulatory mechanisms of the EGR family in tumours and prospects for therapeutic applications (Review).International journal of molecular medicine · 2025Review
- Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells.Cell reports · 2025Article
- Single-cell transcriptomic characterization of microscopic colitis.Nature communications · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.Nature communications · 2025Article
- Single-cell transcriptomics of melanoma sentinel lymph nodes identifies immune cell signatures associated with metastasis.JCI insight · 2025Article
- CD4 T cell dysfunction is associated with bacterial recrudescence during chronic tuberculosis.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
26 authors at 6 institutions in 2 countries.
Mayura V WagleJohn Curtin School of Medical Research, Australian National University, ACT, Australia.
Stephin J VervoortPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Madison J KellyPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0002-2752-9014
Willem Van Der BylThe Kirby Institute for Infection and Immunity, UNSW, Sydney, NSW, Australia.ORCID 0000-0002-8888-8707
Timothy J PetersGarvan Institute of Medical Research, Darlinghurst, NSW, Australia.ORCID 0000-0003-3690-5293
Ben P MartinPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Luciano G MartelottoCentre for Cancer Research, VCCC, University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-9625-1183
Simone NüssingPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Kelly M RamsbottomPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
James R TorpyGarvan Institute of Medical Research, Darlinghurst, NSW, Australia.ORCID 0000-0002-5392-1642
Deborah KnightPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Sinead ReadingPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Kevin ThiaPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Lisa A MiosgeJohn Curtin School of Medical Research, Australian National University, ACT, Australia.
Debbie R HowardJohn Curtin School of Medical Research, Australian National University, ACT, Australia.
Renee GlouryThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Sarah S GabrielThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.
Daniel T UtzschneiderThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0003-2205-9057
Jane OliaroPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0002-2097-6428
Jonathan D PowellBloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University of Medicine, Baltimore, MD, USA.
Fabio LucianiThe Kirby Institute for Infection and Immunity, UNSW, Sydney, NSW, Australia.
Joseph A TrapaniPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Ricky W JohnstonePeter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0001-7053-9237
Axel KalliesThe Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.ORCID 0000-0002-6312-6968
Christopher C Goodnow *John Curtin School of Medical Research, Australian National University, ACT, Australia. c.goodnow@garvan.org.au.ORCID 0000-0001-5296-6155
Ian A Parish *John Curtin School of Medical Research, Australian National University, ACT, Australia. ian.parish@petermac.org.ORCID 0000-0003-3528-478X
The University of Melbourne · AUPeter MacCallum Cancer Centre · AUAustralian National University · AUGarvan Institute of Medical Research · AUUNSW Sydney · AUBloomberg (United States) · US
Funding
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1MNIAID NIH HHS U19 AI100627
Abstract
Chronic stimulation of CD8
Indexed as
AnimalsAntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesClonal AnergyEarly Growth Response Protein 2LymphopoiesisMiceMice, Inbred C57BLMice, KnockoutAntigensEarly Growth Response Protein 2Egr2 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.