Evidence map›Paper›PMID 33986121›Full record

ArticleMolecular cancer research : MCR2021

Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives Neuroendocrine Tumor Progression.

Nathaniel Alzofon, Katrina Koc, Kristin Panwell, Nikita Pozdeyev, Carrie B Marshall, Maria Albuja-Cruz, Christopher D Raeburn, Katherine L Nathanson, Debbie L Cohen, Margaret E Wierman and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Molecular Genetics of Pheochromocytoma/Paraganglioma.Current opinion in endocrine and metabolic research · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Update on the genetics of paragangliomas.Endocrine-related cancer · 2023
    Review
  12. Article
  13. Targeted Therapies in Pheochromocytoma and Paraganglioma.The Journal of clinical endocrinology and metabolism · 2022
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Nathaniel Alzofon *Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.
Katrina Koc *Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.
Kristin PanwellDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.
Nikita PozdeyevDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.
Carrie B MarshallDepartment of Pathology, University of Colorado, Aurora, Colorado.
Maria Albuja-CruzDivision of Trauma, GI and Endocrine Surgery, Department of Surgery, University of Colorado, Aurora, Colorado.
Christopher D RaeburnDivision of Trauma, GI and Endocrine Surgery, Department of Surgery, University of Colorado, Aurora, Colorado.
Katherine L NathansonDepartment of Medicine, Translational Medicine Division and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-6740-0901
Debbie L CohenRenal and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Margaret E WiermanDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.
Katja Kiseljak-VassiliadesDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado.
Lauren FishbeinDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado, Aurora, Colorado. lauren.fishbein@cuanschutz.edu.
University of Colorado Anschutz Medical Campus · USRocky Mountain MS Center · USUniversity of Pennsylvania · US

Funding

Inherited genetic variation and penetrance of Hereditary Paraganglioma-Pheochromocytoma SyndromeR01CA246586 · NCI · UNIVERSITY OF COLORADO DENVER · PI FISHBEIN, LAUREN MICHELLE · 2020 to 2024
$1.8M
Identifying and Characterizing Therapeutic Targets in Adrenal CancerK08CA222620 · NCI · UNIVERSITY OF COLORADO DENVER · PI KISELJAKVASSILIADES, KATJA · 2018 to 2022
$1.0M
BLRD VA I01 BX004665NCI NIH HHS K08 CA222620NCI NIH HHS R01 CA246586
6 · The paper itself

Abstract

Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent

Indexed as

Gene Expression Regulation, NeoplasticAdrenal Gland NeoplasmsApoptosisBiomarkers, TumorCell ProliferationHumansMutationNeuroendocrine TumorsOncogene Proteins, FusionParagangliomaPheochromocytomaTrans-ActivatorsTranscriptomeTumor Cells, CulturedWnt Signaling PathwayBiomarkers, TumorMAML3 protein, humanOncogene Proteins, FusionTrans-Activators

Identifiers

PMID33986121
PMCPMC8419063
OpenAlexW3160181616

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.