Evidence map›Paper›PMID 33986037›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2021

Reinforcing and Stimulant-Like Effects of Methamphetamine Isomers in Rhesus Macaques.

David S Jacobs, Bruce E Blough, Stephen J Kohut

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David S JacobsMcLean Hospital - Harvard Medical School, Belmont, Massachusetts (D.S.J., S.J.K.), and Research Triangle Institute, Research Triangle Park, North Carolina (B.E.B.).
Bruce E BloughMcLean Hospital - Harvard Medical School, Belmont, Massachusetts (D.S.J., S.J.K.), and Research Triangle Institute, Research Triangle Park, North Carolina (B.E.B.).
Stephen J KohutMcLean Hospital - Harvard Medical School, Belmont, Massachusetts (D.S.J., S.J.K.), and Research Triangle Institute, Research Triangle Park, North Carolina (B.E.B.) skohut@mclean.harvard.edu.
RTI International · USMcLean Hospital · US

Funding

BUPRENORPHINE: A BEHAVIORAL ANALYSISR01DA002519 · NIDA · MC LEAN HOSPITAL (BELMONT, MA) · PI BERGMAN, JACK · 1985 to 2018
$6.4M
POTENTIAL TREATMENT MEDICATIONS FOR DRUG ABUSER01DA012970 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI BLOUGH, BRUCE E · 1999 to 2013
$5.5M
Synthetic Psychoactive "Bath Salt" Effects on Brain Activity and BehaviorR01DA048150 · NIDA · MCLEAN HOSPITAL · PI KOHUT, STEPHEN JOHN · 2019 to 2023
$3.7M
Translational models of brain activation patterns during nicotine self-administration and reinstatementK01DA039306 · NIDA · MCLEAN HOSPITAL · PI KOHUT, STEPHEN JOHN · 2015 to 2019
$867k
NIDA NIH HHS K01 DA039306NIDA NIH HHS R01 DA002519NIDA NIH HHS R01 DA012970NIDA NIH HHS R01 DA048150
6 · The paper itself

Abstract

Monoamine releasers such as d-methamphetamine (d-MA) can reduce cocaine use in laboratory studies and have been forwarded for the management of cocaine use disorder (CUD). However, the proven abuse liability of d-MA has limited enthusiasm for clinical use. The levorotatory isomer of MA, l-MA, appears to have lesser stimulant effects, possibly due to its preferential norepinephrine-releasing properties compared with dopamine. The present study evaluated the abuse potential of l-MA by comparing its reinforcing effects with known stimulant drugs of abuse in nonhuman primates. Adult rhesus macaques (

Indexed as

Central Nervous System StimulantsMacaca mulattaMethamphetamineReinforcement, PsychologyAnimalsCocaineFemaleIsomerismMaleReinforcement ScheduleSelf AdministrationCentral Nervous System StimulantsCocaineMethamphetamine

Identifiers

PMID33986037
PMCPMC8407528
OpenAlexW3163912404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.