Evidence map›Paper›PMID 33986021›Full record

ArticleLife science alliance2021

Gametic specialization of centromeric histone paralogs in

Lisa E Kursel, Hannah McConnell, Aida Flor A de la Cruz, Harmit S Malik

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Retention of a singlebioRxiv : the preprint server for biology · 2025
    Article
  3. Centromeres drive and take a break.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Lisa E KurselMolecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA.
Hannah McConnellDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Aida Flor A de la CruzDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA hsmalik@fhcrc.org.ORCID 0000-0001-6005-0016
Howard Hughes Medical Institute · USFred Hutch Cancer Center · USUniversity of Washington · US

Funding

INTERDISCIPLINARY TRAINING IN GENOMIC SCIENCEST32HG000035 · NHGRI · UNIVERSITY OF WASHINGTON · PI Bruce Colston Trapnell · 1995 to 2026
$24.2M
TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Howard Hughes Medical InstituteNHGRI NIH HHS T32 HG000035NIGMS NIH HHS R01 GM074108NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

In most eukaryotes, centromeric histone (CenH3) proteins mediate mitosis and meiosis and ensure epigenetic inheritance of centromere identity. We hypothesized that disparate chromatin environments in soma versus germline might impose divergent functional requirements on single CenH3 genes, which could be ameliorated by gene duplications and subsequent specialization. Here, we analyzed the cytological localization of two recently identified CenH3 paralogs, Cid1 and Cid5, in

Indexed as

AnimalsCentromereCentromere Protein AChromatinDrosophilaDrosophila ProteinsFemaleGene DuplicationGerm CellsHistonesMaleMeiosisMitosisCentromere Protein AChromatinDrosophila ProteinsHistones

Identifiers

PMID33986021
PMCPMC8200288
OpenAlexW3161935190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.