Evidence map›Paper›PMID 33985963›Full record

Observational studyThe British journal of ophthalmology2022

Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals.

Brian Stagg, Eduardo B Mariottoni, Samuel Berchuck, Alessandro Jammal, Angela R Elam, Rachel Hess, Kensaku Kawamoto, Benjamin Haaland, Felipe A Medeiros

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in The British journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

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  17. Big data for imaging assessment in glaucoma.Taiwan journal of ophthalmology
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Brian StaggOphthalmology, Vision, Imaging and Performance (VIP) Laboratory, Duke Eye Center, Durham, North Carolina, USA.ORCID 0000-0003-4023-1885
Eduardo B MariottoniOphthalmology, Vision, Imaging and Performance (VIP) Laboratory, Duke Eye Center, Durham, North Carolina, USA.
Samuel BerchuckOphthalmology, Vision, Imaging and Performance (VIP) Laboratory, Duke Eye Center, Durham, North Carolina, USA.ORCID 0000-0001-5705-3144
Alessandro JammalOphthalmology, Vision, Imaging and Performance (VIP) Laboratory, Duke Eye Center, Durham, North Carolina, USA.
Angela R ElamOphthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Rachel HessPopulation Health Sciences, University of Utah Health, Salt Lake City, Utah, USA.
Kensaku KawamotoBiomedical Informatics, University of Utah, Salt Lake City, Utah, USA.
Benjamin HaalandPopulation Health Sciences, University of Utah Health, Salt Lake City, Utah, USA.
Felipe A MedeirosOphthalmology, Vision, Imaging and Performance (VIP) Laboratory, Duke Eye Center, Durham, North Carolina, USA felipe.medeiros@duke.edu.ORCID 0000-0003-3924-2720
University of Utah · USDuke Medical Center · USDuke University · USUniversity of Michigan · US

Funding

Diagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4M
The BCI (Brain Computer Interface) Glaucoma Study: Objective Home-Based Detection of Progressive Visual Function Loss in GlaucomaR01EY029885 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ASRANI, SANJAY, MEDEIROS, FELIPE · 2019 to 2022
$2.2M
Improving Glaucoma Care Using a Scalable Decision Support SystemK23EY032577 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Brian Stagg · 2022 to 2026
$1.3M
NEI NIH HHS K23 EY032577NEI NIH HHS R01 EY021818NEI NIH HHS R01 EY029885
6 · The paper itself

Abstract

BACKGROUND/

aimsTo investigate racial differences in the variability of longitudinal visual field testing in a 'real-world' clinical population, evaluate how these differences are influenced by socioeconomic status, and estimate the impact of differences in variability on the time to detect visual field progression.

methodsThis retrospective observational cohort study used data from 1103 eyes from 751 White individuals and 428 eyes from 317 black individuals. Linear regression was performed on the standard automated perimetry mean deviation values for each eye over time. The SD of the residuals from the trend lines was calculated and used as a measure of variability for each eye. The association of race with the SD of the residuals was evaluated using a multivariable generalised estimating equation model with an interaction between race and zip code income. Computer simulations were used to estimate the time to detect visual field progression in the two racial groups.

resultsBlack patients had larger visual field variability over time compared with white patients, even when adjusting for zip code level socioeconomic variables (SD of residuals for Black patients=1.53 dB (95% CI 1.43 to 1.64); for white patients=1.26 dB (95% CI 1.14 to 1.22); mean difference: 0.28 (95% CI 0.15 to 0.41); p<0.001). The difference in visual field variability between black and white patients was greater at lower levels of income and led to a delay in detection of glaucoma progression.

conclusionBlack patients had larger visual field variability compared with white patients. This relationship was strongly influenced by socioeconomic status and may partially explain racial disparities in glaucoma outcomes.

Indexed as

GlaucomaVisual FieldsDisease ProgressionFollow-Up StudiesHumansIntraocular PressureRetrospective StudiesVision DisordersVisual Field Testsdiagnostic tests/investigationglaucoma

Identifiers

PMID33985963
PMCPMC8589883
OpenAlexW3162959417

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.