ArticleAJNR. American journal of neuroradiology2021
MRI-Visible Perivascular Spaces in the Centrum Semiovale Are Associated with Brain Amyloid Deposition in Patients with Alzheimer Disease-Related Cognitive Impairment.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Exploring the role of glymphatic system in Alzheimer's disease with insights from MRI-based studies: a systematic review.Neuroradiology · 2026Review
- Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.Annals of neurology · 2026Article
- Altered cerebrospinal fluid-based clearance mechanisms in aging autistic adults.Research square · 2026Article
- Association between MRI indicators of the glymphatic system and cognition in high-risk populations for Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2026Article
- The role of brain MR and FDG-PET in the diagnosis of neurodegenerative disease.European radiology · 2026Review
- Spatial coupling of enlarged perivascular spaces and white matter lesions across the Alzheimer's disease continuum.Frontiers in neuroscience · 2026Article
- Higher basal ganglia perivascular space burden is associated with reduced deep medullary vein visibility via free water accumulation in sporadic cerebral small vessel disease.European journal of medical research · 2025Article
- The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Brain glymphatic fluid mapping in Alzheimer's disease: a human MRI and PET study.Brain communications · 2025Article
- Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease.Frontiers in neuroscience · 2025Article
- A "glympse" into neurodegeneration: Diffusion MRI and cerebrospinal fluid aquaporin-4 for the assessment of glymphatic system in Alzheimer's disease and other dementias.Human brain mapping · 2024Article
- Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Quantitative assessment of enlarged perivascular spaces via deep-learning in community-based older adults reveals independent associations with vascular neuropathologies, vascular risk factors and cognition.Brain communications · 2024Article
- Lifetime history of head injury is associated with reduced perivascular space number in acute mild traumatic brain injury.Brain communications · 2024Article
- Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment.Frontiers in cellular neuroscience · 2024Article
- Effects of sleep on brain perivascular space in a cognitively healthy population.Sleep medicine · 2023Article
- Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia.Neurobiology of aging · 2023Article
- Inflammatory biomarkers and MRI visible perivascular spaces: The Framingham Heart Study.Neurobiology of aging · 2023Article
- Fluid dynamics in aging-related dementias.Neurobiology of disease · 2023Review
- Association between enlarged perivascular spaces and cerebrospinal fluid aquaporin-4 and tau levels: report from a memory clinic.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe association of perivascular spaces in the centrum semiovale with amyloid accumulation among patients with Alzheimer disease-related cognitive impairment is unknown. We evaluated this association in patients with Alzheimer disease-related cognitive impairment and β-amyloid deposition, assessed with [ MATERIALS AND
methodsMR imaging and [
resultsCompared with patients negative for β-amyloid, those positive for it were older and more likely to have lower cognitive function, a diagnosis of Alzheimer disease, white matter hyperintensity, the
conclusionsA high degree of MR imaging-visible perivascular spaces in the centrum semiovale independently predicted β-amyloid positivity in patients with Alzheimer disease-related cognitive impairment. Thus, MR imaging-visible perivascular spaces in the centrum semiovale are associated with amyloid pathology of the brain and could be an indirect imaging marker of amyloid burden in patients with Alzheimer disease-related cognitive impairment.
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