ArticleAJNR. American journal of neuroradiology2021
Functional MRI Shows Altered Deactivation and a Corresponding Decrease in Functional Connectivity of the Default Mode Network in Patients with Gliomas.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Disrupted dynamics of transient brain states in patients with brain tumors: a co-activation pattern analysis of resting-state fMRI.La Radiologia medica · 2026Article
- Resting-State vs. Task-Based Functional Magnetic Resonance Imaging in Neurosurgical Planning: A Narrative Review of Clinical Applications.Biomedicines · 2026Review
- Resting-State Coactivation Patterns of Language Reorganization in Brain Tumors.Neural plasticity · 2026Article
- Relationship between functional network integrity, cognition and fatigue at long-term follow-up in patients with IDH-mutated gliomas.Frontiers in human neuroscience · 2026Article
- Structural-functional fingerprinting for abnormalities investigation in glioma patients.Scientific reports · 2025Article
- Presurgical structural connectivity predicts postsurgical cognitive impairment in glioma patients.Brain communications · 2025Article
- Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review.Cancers · 2023Review
- Language reorganization in patients with left-hemispheric gliomas is associated with increased cortical volume in language-related areas and in the default mode network.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- What Can Resting-State fMRI Data Analysis Explain about the Functional Brain Connectivity in Glioma Patients?Tomography (Ann Arbor, Mich.) · 2022Review
- Alternations and Applications of the Structural and Functional Connectome in Gliomas: A Mini-Review.Frontiers in neuroscience · 2022Review
- Identification of Methamphetamine Abstainers by Resting-State Functional Magnetic Resonance Imaging.Frontiers in psychology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe default mode network normally decreases in activity during externally directed tasks. Although default mode network connectivity is disrupted in numerous brain pathologies, default mode network deactivation has not been studied in patients with brain tumors. We investigated default mode network deactivation with language task-based fMRI by measuring the anticorrelation of a critical default mode network node, the posterior cingulate cortex, in patients with gliomas and controls; furthermore, we examined default mode network functional connectivity in these patients with task-based and resting-state fMRI. MATERIALS AND
methodsIn 10 healthy controls and 30 patients with gliomas, the posterior cingulate cortex was identified on task-based fMRI and was used as an ROI to create connectivity maps from task-based and resting-state fMRI data. We compared the average correlation in each default mode network region between patients and controls for each correlation map and stratified patients by tumor location, hemisphere, and grade.
resultsPatients with gliomas (
conclusionsTask-based fMRI showed impaired deactivation of the default mode network in patients with gliomas. The functional connectivity of the default mode network in both task-based and resting-state fMRI in patients with gliomas using the posterior cingulate cortex identified in task-based fMRI as an ROI for seed-based correlation analysis has strong overlap.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.