Evidence map›Paper›PMID 33985553›Full record

ArticleJournal of orthopaedic surgery and research2021

Genetic variant of MIR4300HG is associated with progression of adolescent idiopathic scoliosis in a Chinese population.

Yuwen Wang, Zhicheng Dai, Zhichong Wu, Zhenhua Feng, Zhen Liu, Xu Sun, Leilei Xu, Yong Qiu, Zezhang Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuwen Wang *Department of Spine Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Zhongshan Road 321, Nanjing, 210008, China.
Zhicheng Dai *Department of Spine Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Zhongshan Road 321, Nanjing, 210008, China.
Zhichong WuDepartment of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhenhua FengDepartment of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhen LiuDepartment of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Xu SunDepartment of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Leilei XuDepartment of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Yong QiuDepartment of Spine Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Zhongshan Road 321, Nanjing, 210008, China.
Zezhang ZhuDepartment of Spine Surgery, Drum Tower Hospital Clinical College of Nanjing Medical University, Zhongshan Road 321, Nanjing, 210008, China. zhuzezhang@126.com.
Nanjing Drum Tower Hospital · CN

Funding

Joint Research Scheme sponsored by the National Natural Science Foundation of China and the Research Grants Council of the Hong Kong Special Administrative Region N_CUHK416/16Natural Science Foundation of Jilin Province No. 81871747 & No.81661168013, No. 8197090027, No. 81772304
6 · The paper itself

Abstract

backgroundA recent genome-wide association study identified a susceptible locus in MIR4300HG gene that was associated with curve progression of adolescent idiopathic scoliosis (AIS) in the Japanese population. However, the association between the gene and curve progression in other populations remains unclear.

methodsA cohort of 1952 AIS patients and 2495 healthy controls were included in the case-control analysis. In the case-only analysis, 747 patients were assigned to the progression group and 520 patients were assigned to the non-progression group, respectively. Rs35333564 was genotyped for all the subjects. Paraspinal muscles of 76 patients were collected for the analysis of gene expression. Chi-square test and ANOVA test were used for the intergroup comparison. Pearson correlation analysis was performed to investigate the relationship between the gene expression and curve magnitude.

resultsVariant rs35333564 was significantly associated with the curve severity of AIS (p = 0.025), but not the development of AIS (p = 0.418). Genotype GG was indicated by remarkably lower expression of MIR4300 (p = 0.020) which was significantly correlated with curve magnitude (p = 0.010). As a predicted target gene of MIR4300, the expression of CRTC1 was negatively correlated with MIR4300 expression (p = 0.012, r = -0.287) and positively correlated with curve severity (p = 0.025, r = 0.257).

conclusionsThe association between rs35333564 and curve progression was successfully replicated in a Chinese AIS population. CRTC1 may be the target gene of MIR4300 that plays a role in the curve progression of AIS.

Indexed as

Disease ProgressionAdolescentCase-Control StudiesChildChinaFemaleGene ExpressionGenome-Wide Association StudyGenotypeHumansRetrospective StudiesScoliosisSeverity of Illness IndexAdolescent idiopathic scoliosisCurve progressionGenetic variantMIR4300HG

Identifiers

PMID33985553
PMCPMC8117547
OpenAlexW3163086702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.