ArticleWorld journal of surgical oncology2021
Prognostic value of regional lymph node involvement in patients with metastatic colorectal cancer: palliative versus curative resection.
Article in World journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 24 citations in OpenAlex.
- Prognostic divergence of hematogenous and lymphatic metastases in surgically treated patients with stage IV colorectal cancer.International journal of colorectal disease · 2026Article
- Association of the tumor microenvironment collagen score and immunoscore with colon cancer lymph node metastasis.BMC cancer · 2025Article
- Integrating proteomics and machine learning reveals characteristics and risks of lymph node-independent distant metastasis in colorectal cancer.Frontiers in immunology · 2025Article
- Risk factors and a predictive nomogram for regional lymph node metastasis in deficient mismatch repair colorectal cancer.Frontiers in oncology · 2025Article
- Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives.Signal transduction and targeted therapy · 2024Review
- Article
- Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling Approach.The American journal of pathology · 2023Article
- Reprogramming of sentinel lymph node microenvironment during tumor metastasis.Journal of biomedical science · 2022Review
- Decision-making in postoperative chemotherapy for ovarian metastasis from colorectal cancer: a retrospective single-center study.World journal of surgical oncology · 2022Article
- Clinical analysis of metastatic characteristics of infrapyloric lymph nodes (No.206) and terminal ileum lymph nodes in patients with right colon cancer.World journal of surgical oncology · 2021Article
- Higher titer hepatitis B core antibody predicts a higher risk of liver metastases and worse survival in patients with colorectal cancer.World journal of surgical oncology · 2021Article
- Prognostic factors for ovarian metastases in colorectal cancer patients.World journal of surgical oncology · 2021Article
- Tumor size measured by multidetector CT in resectable colon cancer: correlation with regional lymph node metastasis and N stage.World journal of surgical oncology · 2021Article
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9 authors at 2 institutions in 1 country.
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Abstract
backgroundApproximately 20% of patients with colorectal cancer are initially diagnosed with stage IV disease. This study aims to examine the role of regional lymph node (LN) status in metastatic colorectal cancer (mCRC) with respect to clinicopathologic features and survival outcomes.
methodsWe investigated 1147 patients diagnosed with mCRC and had undergone surgical resection of the primary CRC. A total of 167 patients were placed in the LN-negative (LN-) group and another 980 in the LN-positive (LN+) group.
resultsLN+ patients exhibited a significantly higher rate of T4 tumors (p = 0.008), poorly differentiated adenocarcinoma (p < 0.001), lymphovascular invasion (p < 0.001), and perineural invasion (p < 0.001) than those in the LN- group. LN- patients had a significantly higher rate of lung metastasis (p < 0.001), whereas the rate of peritoneal seeding (p < 0.001) and systemic node metastasis (p < 0.001) was both significantly higher in the LN+ group. The 5-year overall survival (OS) in the LN+ group was significantly poorer than that in the LN- group (LN- vs. LN+ 23.2% vs. 18.1%; p = 0.040). In patients with curative resection, the 5-year OS rate has no significant difference between the two groups (LN- vs. LN+ 19.5% vs. 24.3%; p = 0.890).
conclusionsMetastatic CRC patients with LN+ who underwent primary tumor resection may present with more high-risk pathological features, more peritoneal seeding, and systemic node metastasis, but less lung metastasis than LN- patients. LN+ patients had poorer long-term outcomes compared with that in LN- patients. Nevertheless, with curative resection, LN+ patients could have similar survival outcomes as LN- patients.
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