Evidence map›Paper›PMID 33985511›Full record

ArticleJournal of nanobiotechnology2021

Dimeric Her2-specific affibody mediated cisplatin-loaded nanoparticles for tumor enhanced chemo-radiotherapy.

Haijun Wang, Dianlong Jia, Dandan Yuan, Xiaolei Yin, Fengjiao Yuan, Feifei Wang, Wenna Shi, Hui Li, Li-Min Zhu, Qing Fan

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Haijun Wang *Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China.
Dianlong Jia *Laboratory of Drug Discovery and Design, School of Pharmacy, Liaocheng University, Liaocheng, 252000, China.
Dandan YuanDepartment of Digestive Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China.
Xiaolei YinSchool of Life Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271016, China.
Fengjiao YuanJoint Laboratory for Translational Medicine Research, Liaocheng People's Hospital, Liaocheng, 252000, China.
Feifei WangLaboratory of Drug Discovery and Design, School of Pharmacy, Liaocheng University, Liaocheng, 252000, China.
Wenna ShiDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China.
Hui LiDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China.
Li-Min ZhuCollege of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China. lzhu@dhu.edu.cn.ORCID http://orcid.org/0000-0003-1580-6851
Qing FanDepartment of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China. qingfan0708@yahoo.com.
Shandong Tumor Hospital · CNLiaocheng University · CNDonghua University · CNLiaocheng People's Hospital · CNShandong First Medical University · CN

Funding

Natural Science Foundation of Shandong Province ZR2019PH006Natural Science Foundation of Shandong Province ZR2020QH347Science and Technology Commission of Shanghai Municipality 16410723700Shandong Provincial Key Research Development Program 2018GSF118175Youth Innovative Science and Technology Program of Shandong Colleges and University 2019KJM012
6 · The paper itself

Abstract

backgroundSolid tumor hypoxic conditions prevent the generation of reactive oxygen species (ROS) and the formation of DNA double-strand breaks (DSBs) induced by ionizing radiation, which ultimately contributes to radiotherapy (RT) resistance. Recently, there have been significant technical advances in nanomedicine to reduce hypoxia by facilitating in situ O

resultsHuman epidermal growth factor receptor 2 (Her2)-specific dimeric affibody (Z

conclusionsThe nanocarriers described in the present study integrated Her2 targeting, diagnosis and RT sensitization into a single platform, thus providing a novel approach for translational tumor theranostics.

Indexed as

AnimalsCell Line, TumorChemoradiotherapyCisplatinDrug Delivery SystemsDrug LiberationErb-b2 Receptor Tyrosine KinasesEscherichia coliFemaleHumansManganese CompoundsMiceMice, Inbred BALB CMice, NudeNanoparticlesOxidesCisplatinERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesManganese CompoundsOxidesPolymersRadiation-Sensitizing AgentsReactive Oxygen SpeciesDimeric Her2-specific affibodyMesoporous polydopamineMnO2RadiosensitizationTumor hypoxia

Identifiers

PMID33985511
PMCPMC8120847
OpenAlexW3135712462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.