ArticleBMC plant biology2021
Comparative transcriptome profiling and co-expression network analysis uncover the key genes associated withearly-stage resistance to Aspergillus flavus in maize.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 73 citations in OpenAlex.
- Identification of ZmGLN5, a candidate gene for resistance to Gibberella ear rot in maize.Molecular biology reports · 2026Article
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- The molecular revolution in fungal diagnostics: bridging gaps across clinical, agricultural, and environmental mycology.Mycology · 2026Review
- Microbiome Analysis Reveals Biocontrol ofPlants (Basel, Switzerland) · 2025Article
- Regulatory balance between ear rot resistance and grain yield and their breeding applications in maize and other crops.Journal of advanced research · 2025Review
- Comparative transcriptome profiling and co-expression network analysis reveals important genes regulating maize response to Southern corn rust.BMC plant biology · 2025Article
- Transcriptome and WGCNA Reveal the Key Genes of Arbuscular Mycorrhizal Fungi in Regulating Sugarcane Growth and Nutrient Absorption.Food science & nutrition · 2025Article
- The Effect ofPlants (Basel, Switzerland) · 2025Article
- Comparative transcriptome and genome analysis between susceptible Zhefang rice variety Diantun 502 and its resistance variety Diantun 506 upon Magnaporthe oryzae infection.BMC plant biology · 2025Article
- Predictive prioritization of genes significantly associated with biotic and abiotic stresses in maize using machine learning algorithms.Frontiers in plant science · 2025Article
- Genome-wide transcriptome and gene family analysis reveal candidate genes associated with potassium uptake of maize colonized by arbuscular mycorrhizal fungi.BMC plant biology · 2024Article
- Comparative transcriptome and coexpression network analysis revealed the regulatory mechanism of Astragalus cicer L. in response to salt stress.BMC plant biology · 2024Article
- A dual RNA-seq analyses revealed dynamic arms race during the invasion of walnut by Colletotrichum gloeosporioides.BMC plant biology · 2024Article
- Article
- Cytological and transcriptomic analysis to unveil the mechanism of web blotch resistance in Peanut.BMC plant biology · 2023Article
- Plant-Fungi Interactions: Where It Goes?Biology · 2023Review
- Article
- Brown midrib mutant and genome-wide association analysis uncover lignin genes for disease resistance in maize.The plant genome · 2023Article
- Promoter activity and transcriptome analyses decipher functions of CgbHLH001 gene (Chenopodium glaucum L.) in response to abiotic stress.BMC plant biology · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe fungus Aspergillus flavus (A. flavus) is a serious threat to maize (Zea mays) production worldwide. It causes considerable yield and economic losses, and poses a health risk to humans and livestock due to the high toxicity of aflatoxin. However, key genes and regulatory networks conferring maize resistance to A. flavus are not clear, especially at the early stage of infection. Here, we performed a comprehensive transcriptome analysis of two maize inbred lines with contrasting resistance to A. flavus infection.
resultsThe pairwise comparisons between mock and infected kernels in each line during the first 6 h post inoculation (hpi) showed that maize resistance to A. flavus infection was specific to the genotype and infection stage, and defense pathways were strengthened in the resistant line. Further comparison of the two maize lines revealed that the infection-induced up-regulated differentially expressed genes (DEGs) in the resistant line might underlie the enhanced resistance. Gene co-expression network analysis by WGCNA (weighted gene co-expression network analysis) identified 7 modules that were significantly associated with different infection stages, and 110 hub genes of these modules. These key regulators mainly participate in the biosynthesis of fatty acid and antibiotics. In addition, 90 candidate genes for maize resistance to A. flavus infection and/or aflatoxin contamination obtained in previous studies were confirmed to be differentially expressed between the resistant and susceptible lines within the first 6 hpi.
conclusionThis work unveiled more A. flavus resistance genes and provided a detailed regulatory network of early-stage resistance to A. flavus in maize.
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