Evidence map›Paper›PMID 33985416›Full record

ArticleGut microbes

Melinda A Engevik, Beatrice Herrmann, Wenly Ruan, Amy C Engevik, Kristen A Engevik, Faith Ihekweazu, Zhongcheng Shi, Berkley Luck, Alexandra L Chang-Graham, Magdalena Esparza and 9 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  7. Review
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  14. Article
  15. Article
  16. Interactions betweeniMetaOmics · 2025
    Article
  17. Review
  18. EnterohemorrhagicPathogens (Basel, Switzerland) · 2025
    Article
  19. Gene-trait matching amongFrontiers in microbiology · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Melinda A EngevikDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-9742-9932
Beatrice HerrmannDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-2508-9043
Wenly RuanDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0391-5543
Amy C EngevikDepartment of Surgery, Vanderbilt University Medical Center, Nashville TN, USA.ORCID 0000-0001-9108-3240
Kristen A EngevikDepartment of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9807-1875
Faith IhekweazuDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-9800-8590
Zhongcheng ShiDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9267-4536
Berkley LuckDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-5996-876X
Alexandra L Chang-GrahamDepartment of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-3403-6787
Magdalena EsparzaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.
Susan VenableDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-8752-1092
Thomas D HorvathDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9761-3484
Sigmund J HaidacherDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-6103-1906
Kathleen M HochDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-7867-1221
Anthony M HaagDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-3547-2812
Deborah A SchadyDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0150-4660
Joseph M HyserDepartment of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX, USA.
Jennifer K SpinlerDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-7830-7665
James VersalovicDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-5765-4385
Baylor College of Medicine · USVanderbilt University Medical Center · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Geoffrey A Preidis · 2001 to 2026
$28.3M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Research Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4M
Training Supplement in Enteric Virus Exploitation of Calcium SignalingR01DK115507 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Joseph M. Hyser · 2018 to 2026
$5.0M
Gut L-Histidine Metabolism and Histamine Signaling in Colonic NeoplasiaU01CA170930 · NCI · BAYLOR COLLEGE OF MEDICINE · PI VERSALOVIC, JAMES · 2013 to 2017
$2.8M
The role of Myosin Vb in Hepatocyte Protein TraffickingK01DK121869 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGEVIK, AMY C · 2019 to 2023
$669k
Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612k
Regulation of secretory diarrhea by ER-PM junction signalingF30DK112563 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI CHANG-GRAHAM, ALEXANDRA · 2017 to 2019
$128k
NCI NIH HHS U01 CA170930NIDDK NIH HHS F30 DK112563NIDDK NIH HHS K01 DK121869NIDDK NIH HHS K01 DK123195NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK123704NIDDK NIH HHS R01 DK115507NIDDK NIH HHS T32 DK007664
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although

Indexed as

Endoplasmic Reticulum StressAnimalsBifidobacteriumColitisColonDipeptidesEndoplasmic Reticulum Chaperone BiPGastrointestinal MicrobiomeGoblet CellsHumansMaleMiceMucin-2Trinitrobenzenesulfonic AcidDipeptidesEndoplasmic Reticulum Chaperone BiPgamma-glutamylcysteineHSPA5 protein, humanHspa5 protein, mouseMucin-2Trinitrobenzenesulfonic AcidbifidobacteriacolitisER-stressgoblet cellsIBDIL-10MUC2organoids

Identifiers

PMID33985416
PMCPMC8128206
OpenAlexW3160033051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.