Evidence map›Paper›PMID 33985385›Full record

Trial reportVascular medicine (London, England)2021

Effects of intermittent negative pressure treatment on circulating vascular biomarkers in patients with intermittent claudication.

Henrik Hoel, Erik Mulder Pettersen, Lars Øivind Høiseth, Iacob Mathiesen, Arne Seternes, Ingebjørg Seljeflot, Jonny Hisdal

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vascular medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review.International journal of molecular sciences · 2021
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Henrik HoelInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-1891-1614
Erik Mulder PettersenDepartment of Surgery, Sørlandet Hospital, Kristiansand, Norway.
Lars Øivind HøisethDepartment of Anesthesiology, Oslo University Hospital, Oslo, Norway.
Iacob MathiesenOtivio AS, Oslo, Norway.
Arne SeternesDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Ingebjørg SeljeflotInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Jonny HisdalInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Oslo University Hospital · NONorwegian University of Science and Technology · NOOtivio (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the effects of lower extremity intermittent negative pressure (INP) treatment for 1 hour twice daily for 12 weeks, on circulating vascular biomarkers in patients with intermittent claudication. Patients were randomized to treatment with -40 mmHg INP (treatment group), or -10 mmHg INP (sham control group). Venous blood samples were collected at baseline and after 12 weeks, and concentrations of vascular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1), E-selectin, P-selectin, von Willebrand factor (vWF), l-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were analyzed. A larger proportion of the patients in the treatment group (25/31) had a reduction in vWF levels after 12 weeks, compared to the sham control group (17/30) (

Indexed as

Cell Adhesion MoleculesIntermittent ClaudicationBiomarkersHumansLower Extremityvon Willebrand FactorBiomarkersCell Adhesion Moleculesvon Willebrand Factorintermittent claudicationintermittent negative pressure treatmentperipheral artery disease (PAD)vascular endotheliumvascular medicine

Identifiers

PMID33985385
PMCPMC8493410
OpenAlexW3162590016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.