ArticleEndocrine connections2021
Clinical impacts of endothelium-dependent flow-mediated vasodilation assessment on primary aldosteronism.
Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Meta-analysis of blood parameters related to lipid and glucose metabolism between two subtypes of primary aldosteronism.Journal of clinical hypertension (Greenwich, Conn.) · 2023Pooled it
- Prospective study of primary aldosteronism in acute ischemic stroke: association with small vessel disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Comparisons of risk factors for post-treatment renal dysfunction between the two major subtypes of primary aldosteronism.Endocrine · 2024Article
- Cardiovascular risk assessments in patients with cortisol-producing adenoma: impact of clinical features and genetic characteristics.Heart and vessels · 2024Article
- Emerging association between KCNJ5 mutations and vascular failure in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Improving the Effects of Imeglimin on Endothelial Function: A Prospective, Single-Center, Observational Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrimary aldosteronism (PA) is divided into two major subtypes, aldosterone-producing adenoma (APA) and bilateral idiopathic hyperplasia (IHA) and is associated with a higher risk of cardiovascular events. However, the nature of vascular function in PA patients remains to be determined. The aim of this study was to determine the vascular function and investigate the implications of vascular function assessments in the patients.
methodsFlow-mediated dilation (FMD), as an index of endothelial function, and cardio-ankle vascular index (CAVI), as an index of arterial stiffness, were retrospectively compared between 42 patients with APA, 37 patients with IHA, and 42 patients with essential hypertension (EH). These values were also compared with background factors, KCNJ5 mutation and clinical outcome in terms of blood pressure reduction after adrenalectomy in the APA group.
resultsFMD was significantly lower in the APA group (4.8 ± 2.1%) and IHA group (4.1 ± 1.9%) than in the EH group (5.7 ± 2.1%). CAVI did not differ significantly among groups. Although no significant correlations were seen between FMD and background factors in the IHA group, FMD correlated negatively with BMI and plasma aldosterone concentration in the APA group (rs = -0.313, rs = -0.342, respectively). KCNJ5 mutational status was not associated with FMD value. High FMD was associated with blood pressure normalization after adrenalectomy in the APA group.
conclusionsPatients with PA displayed impaired endothelial function. Complete clinical success after adrenalectomy was associated with preserved endothelial function. This study provides a better understanding of FMD assessment in patients with PA.
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