Trial reportContemporary clinical trials2021
Cancer Health Assessments Reaching Many (CHARM): A clinical trial assessing a multimodal cancer genetics services delivery program and its impact on diverse populations.
Trial report in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03426878 (Exome Sequencing in Diverse Populations in Colorado & Oregon), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exome Sequencing in Diverse Populations in Colorado & Oregon
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Pooled it
- ORCA, a values-based decision aid for selecting additional findings from genomic sequencing in adults: Efficacy results from a randomized trial.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Trial
- Maintaining Quality of Genetic Counseling Services While Maximizing Efficiency: Protocol for the GC-PRO Intervention Stepped-Wedge Cluster Randomized Trial.Journal of genetic counseling · 2026Article
- Patient-initiated lifestyle changes following receipt of genetic test results in a predominantly marginalized population.Journal of genetic counseling · 2025Article
- Improving genetics equity: identifying women eligible for genetic care services using mammography clinics in underserved areas as screening hubs.The oncologist · 2025Article
- Call to action for genetic counseling research in hereditary cancer: Considerations from the evidence-based guidelines development process.Journal of genetic counseling · 2025Article
- Using a behaviour-change approach to support uptake of population genomic screening and management options for breast or prostate cancer.European journal of human genetics : EJHG · 2025Article
- Measuring perceived utility of genomic sequencing: Development and validation of the GENEtic Utility (GENE-U) scale for adult screening.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Article
- Evaluation of mailed results versus telephone disclosure of normal cancer genetic test results in a low-risk underserved population.Translational behavioral medicine · 2024Article
- Feasibility of an electronic patient-facing cancer family history tool in medically underserved populations.Genetics in medicine open · 2024Article
- Improving Care for Marginalized Populations at Risk for Hereditary Cancer Syndromes: Innovations that Expanded Reach in the CHARM Study.Public health genomics · 2024Article
- Most people share genetic test results with relatives even if the findings are normal: Family communication in a diverse population.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Article
- Patient priorities for fulfilling the principle of respect in research: findings from a modified Delphi study.BMC medical ethics · 2023Article
- Risk management actions following genetic testing in the Cancer Health Assessments Reaching Many (CHARM) Study: A prospective cohort study.Cancer medicine · 2023Article
- Medical interpreter-mediated genetic counseling for Spanish preferring adults at risk for a hereditary cancer syndrome.Journal of genetic counseling · 2023Article
- Evaluating cancer genetic services in a safety net system: overcoming barriers for a lasting impact beyond the CHARM research project.Journal of community genetics · 2023Article
- Conducting clinical genomics research during the COVID-19 pandemic: Lessons learned from the CSER consortium experience.American journal of medical genetics. Part A · 2023Article
- Promoting equity, inclusion, and efficiency: A team science approach to the development of authorship guidelines for a multi-disciplinary research team.Journal of clinical and translational science · 2023Article
- Disparities in cancer genetics care by race/ethnicity among pan-cancer patients with pathogenic germline variants.Cancer · 2022Article
- Literacy-adapted, electronic family history assessment for genetics referral in primary care: patient user insights from qualitative interviews.Hereditary cancer in clinical practice · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
28 authors at 7 institutions in 1 country.
Funding
Abstract
Advances in the application of genomic technologies in clinical care have the potential to increase existing healthcare disparities. Studies have consistently shown that only a fraction of eligible patients with a family history of cancer receive recommended cancer genetic counseling and subsequent genetic testing. Care delivery models using pre-test and post-test counseling are not scalable, which contributes to barriers in accessing genetics services. These barriers are even more pronounced for patients in historically underserved populations. We have designed a multimodal intervention to improve subsequent cancer surveillance, by improving the identification of patients at risk for familial cancer syndromes, reducing barriers to genetic counseling/testing, and increasing patient understanding of complex genetic results. We are evaluating this intervention in two large, integrated healthcare systems that serve diverse patient populations (NCT03426878). The primary outcome is the number of diagnostic (hereditary cancer syndrome) findings. We are examining the clinical and personal utility of streamlined pathways to genetic testing using electronic medical record data, surveys, and qualitative interviews. We will assess downstream care utilization of individuals receiving usual clinical care vs. genetic testing through the study. We will evaluate the impacts of a literacy-focused genetic counseling approach versus usual care genetic counseling on care utilization and participant understanding, satisfaction, and family communication. By recruiting participants belonging to historically underserved populations, this study is uniquely positioned to evaluate the potential of a novel genetics care delivery program to reduce care disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.