Evidence map›Paper›PMID 33984461›Full record

ArticleJournal of pain and symptom management2021

Compassion Inequities and Opioid Use Disorder: A Matched Case-Control Analysis Examining Inpatient Management of Cancer-Related Pain for Patients With Opioid Use Disorder.

Sarah A Singh, Rachel A Moreland, Wei Fang, Parvez Shaikh, John Michael Perez, Ann M Morris, Basem Dahshan, Rebecca F Krc, Dilip Chandran, Monika Holbein

Abstract read
In one paragraph

Article in Journal of pain and symptom management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  5. The US Cancer Pain Crisis and the Global Pain Divide: Can Two Wrongs Make It Right?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah A SinghDepartment of Radiation Oncology, West Virginia University, Morgantown, West Virginia, USA. Electronic address: sarah.amrita.singh@gmail.com.
Rachel A MorelandDepartment of Psychiatry, West Virginia University, Morgantown, West Virginia, USA.
Wei FangDepartment of Biostatistics, Clinical and Translational Science Institute, West Virginia University Health Sciences Center Erma Byrd Biomedical Research Center, Morgantown, West Virginia, USA.
Parvez ShaikhDepartment of Radiation Oncology, West Virginia University, Morgantown, West Virginia, USA.
John Michael PerezDepartment of Psychiatry, West Virginia University, Morgantown, West Virginia, USA.
Ann M MorrisDepartment of Radiation Oncology, West Virginia University, Morgantown, West Virginia, USA.
Basem DahshanDepartment of Radiation Oncology, West Virginia University, Morgantown, West Virginia, USA.
Rebecca F KrcDepartment of Radiation Oncology, West Virginia University, Morgantown, West Virginia, USA.
Dilip ChandranDepartment of Psychiatry, West Virginia University, Morgantown, West Virginia, USA.
Monika HolbeinDepartment of Hematology and Oncology, West Virginia University, Morgantown, West Virginia, USA.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

contextThe opioid epidemic spurred guidelines intended to reduce inappropriate prescribing. Although acute cancer-related pain was excluded from these recommendations, studies demonstrate reduced opioid prescribing for patients hospitalized with advanced cancer.

objectivesWe performed a matched case-control analysis to determine how a history of opioid use disorder (OUD) affects inpatient management of cancer pain.

methodsCharts of patients with OUD admitted for cancer pain from 2015-2020 were retrospectively reviewed. Hospitalizations were matched 1:1 by patient age and sex. Home milligram-morphine equivalent per day (MME/day) was calculated from the home medication list. Admission MME/day was the average MME/day administered during hospitalization.

resultsA total of 80 hospitalizations (40:40) were matched for 25 patients with a history of OUD and 31 patients with no history of OUD. Cancer was metastatic/relapsed for 70% of admissions. The median overall survival was 2.3 months (95% CI 0-5.21, P = 0.13). Patients with OUD had a significantly lower change from Home to Admission MME/day (-3 vs. 37, P < 0.01) and were less likely to have any increase in Admission MME/day (OR 0.1, 95% CI 0.02-0.43, P < 0.01). When considering opioids administered after pain specialty consultation, there was no difference between groups.

conclusionOur results suggest that patients with OUD receive lower quality inpatient management of cancer-related pain. Provider education and early involvement of pain specialists are crucial in delivering equitable and compassionate end-of-life care for patients with OUD.

Indexed as

Cancer PainNeoplasmsOpioid-Related DisordersAnalgesics, OpioidEmpathyHumansInpatientsPractice Patterns, Physicians'Retrospective StudiesAnalgesics, Opioidhealth disparitiesOpioid use disorderpalliative care

Identifiers

PMID33984461
PMCPMC8416788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.