Evidence map›Paper›PMID 33984398›Full record

ArticleJournal of virological methods2021

Accessioning and automation compatible anterior nares swab design.

Mary E Pettit, Sarah A Boswell, Jason Qian, Richard Novak, Michael Springer

Abstract readComparative Study
In one paragraph

Article in Journal of virological methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. ACS omega · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mary E PettitDepartment of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Sarah A BoswellDepartment of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA.
Jason QianDepartment of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, 02115, USA.
Richard NovakWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
Michael SpringerDepartment of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA, 20115, USA. Electronic address: michael_springer@hms.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has resulted in an unparalleled need for viral testing capacity across the world and is a critical requirement for successful re-opening of economies. The logistical barriers to near-universal testing are considerable. We have designed an injection molded polypropylene anterior nares swab, the Rhinostic, with a screw cap integrated into the swab handle that is compatible with fully automated sample accessioning and processing. The ability to collect and release both human and viral material is comparable to that of several commonly used swabs on the market. SARS-CoV-2 is stable on dry Rhinostic swabs for at least 3 days, even at 42 °C, and elution can be achieved with small volumes. To test the performance of the Rhinostic in patients, 119 samples were collected with Rhinostic and the positive and negative determinations were 100 % concordant with samples collected using Clinical Laboratory Improvement Amendments (CLIA) use approved nasal swabs at a clinical lab. The Rhinostic swab and barcoded tube set can be produced, sterilized, and packaged cost effectively and is designed to be adopted by clinical laboratories using automation to increase throughput and dramatically reduce the cost of a standard SARS-CoV-2 detection pipeline.

Indexed as

Automation, LaboratoryCOVID-19 Nucleic Acid TestingHumansNasopharynxPolypropylenesRNA, ViralSARS-CoV-2Specimen HandlingPolypropylenesRNA, ViralAN swabCOVID-19DetectionNasal swabSARS-CoV-2

Identifiers

PMID33984398
PMCPMC8108477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.