ArticleDevelopmental cell2021
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.
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In one paragraph
Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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0cells of the map it votes in
37citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
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Who cites it
37 citing papers in PubMed, 50 citations in OpenAlex.
- Age and sex shape plasma lipid associations to skeletal muscle mitochondrial respiration and HGeroScience · 2026Article
- Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy.Journal of enzyme inhibition and medicinal chemistry · 2026Article
- PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.Translational stroke research · 2026Article
- PI4K and PIPK families in breast cancer: subtype-specific oncogenic mechanisms and precision therapeutic strategies.Molecular biology reports · 2026Review
- Synthesis and characterization of a novel phosphatidylinositol 5-phosphate (PI(5)P) photoaffinity probe.RSC chemical biology · 2026Article
- Article
- A proximity-labeling map of PI5P4K phosphoinositide kinases interaction networks.The Journal of biological chemistry · 2026Article
- Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B.Acta crystallographica. Section D, Structural biology · 2026Article
- Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer.Journal of advanced research · 2026Article
- Noncanonical PI(4,5)PScience advances · 2026Article
- Subcellular Cartography of the Phosphoinositide Multiverse.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2026Review
- PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer.Cell reports · 2025Article
- PI5P4K inhibitors: promising opportunities and challenges.The FEBS journal · 2025Review
- Mitochondrial metabolism and cancer therapeutic innovation.Signal transduction and targeted therapy · 2025Review
- Cross-comparison of strains used for mitochondrial imaging inLife science alliance · 2025Article
- The oily nucleus- role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm.Cellular and molecular life sciences : CMLS · 2025Review
- Downregulation of PIP4K2C inhibits the breast cancer cell proliferation, migration and invasion.Translational oncology · 2025Article
- Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities.Nature reviews. Cancer · 2025Review
- Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP.Science signaling · 2024Article
- The peroxisome: an update on mysteries 3.0.Histochemistry and cell biology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 2 countries.
Archna RaviCell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Lavinia PalamiucCell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Ryan M LoughranCell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Joanna TriscottDepartment of Biomedical Research and Bern Center for Precision Medicine, University of Bern and Inselspital Bern, Bern 3008, Switzerland.
Gurpreet K AroraCell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Avi KumarDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Vivian TieuCell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Chantal PauliInstitute of Pathology and Molecular Pathology, University Hospital Zürich and the University of Zurich (UZH), Zurich 8006, Switzerland.
Matthias ReistDepartment of Biomedical Research and Bern Center for Precision Medicine, University of Bern and Inselspital Bern, Bern 3008, Switzerland.
Rachel J LewGladstone Institutes, San Francisco, CA 94158, USA.
Shauna L HoulihanCancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Christof FellmannGladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.
Christian MetalloDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Mark A RubinDepartment of Biomedical Research and Bern Center for Precision Medicine, University of Bern and Inselspital Bern, Bern 3008, Switzerland.
Brooke M EmerlingCell and Molecular Biology of Cancer Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: bemerling@sbpdiscovery.org.
Sanford Burnham Prebys Medical Discovery Institute · USUniversity Hospital of Bern · CHDiscovery Institute · USUniversity of California, San Diego · USGladstone Institutes · USMemorial Sloan Kettering Cancer Center · USUniversity of California, San Francisco · USUniversity of Zurich · CH
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MNon-Canonical Phosphatidylinositol Kinases in Triple Negative Breast CancerR01CA237536 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI EMERLING, BROOKE M · 2020 to 2024
$2.2MMechanism and Therapeutic Application of RNA-Guided Immune SystemsR00GM118909 · NIGMS · J. DAVID GLADSTONE INSTITUTES · PI FELLMANN, CHRISTOF · 2018 to 2020
$747kNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA237536NIGMS NIH HHS R00 GM118909
Abstract
PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4,5-P
Indexed as
AnimalsCarcinogenesisCell Line, TumorEnergy MetabolismFemaleHomeostasisHumansLipid DropletsLipid MetabolismMaleMiceMitochondriaNeoplasmsPeroxisomesPhosphotransferases (Alcohol Group Acceptor)Phosphotransferases (Alcohol Group Acceptor)PIP4K2A protein, humancancerfatty acidlipidlipid dropletmetabolismmitochondriaperoxisomephosphoinositidephosphoinositide kinasePI-4,5-P(2)PI-5-PPI5P4Kssarcomaβ-oxidation
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.