ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Timing and Duration of Prediabetic Metabolic Dysfunction Differentially Impact Cerebral Perfusion, Vascular Structure, and Behavior.Journal of cardiovascular translational research · 2026Article
- Cumulative poverty across early adulthood and midlife cognition: findings from the national longitudinal survey of youth.Journal of epidemiology and community health · 2026Article
- Skeletal muscle adiposity and cognitive decline in a biracial cohort: Insights from coronary artery risk development in young adults (CARDIA) study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An Introduction to Longitudinal Synthetic Cohorts for Studying the Life Course Drivers of Health Outcomes and Inequalities in Older Age.Current epidemiology reports · 2025Article
- High-fat feeding has sex-dependent effects on the structure and biomechanical properties of cerebral parenchymal arterioles and cognitive function.American journal of physiology. Heart and circulatory physiology · 2025Article
- Emerging Theories of Allostatic-Interoceptive Overload in Neurodegeneration.Current topics in behavioral neurosciences · 2025Review
- Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations.The lancet. Healthy longevity · 2024Review
- Associations of metabolic heterogeneity of obesity with the risk of dementia in middle-aged adults: three prospective studies.Alzheimer's research & therapy · 2024Article
- Overcoming Data Gaps in Life Course Epidemiology by Matching Across Cohorts.Epidemiology (Cambridge, Mass.) · 2024Article
- CCR2Brain, behavior, and immunity · 2024Article
- A synergetic turn in cognitive neuroscience of brain diseases.Trends in cognitive sciences · 2024Review
- Intrinsic timescales and predictive allostatic interoception in brain health and disease.Neuroscience and biobehavioral reviews · 2024Review
- Early Life Obesity Increases Neuroinflammation, Amyloid Beta Deposition, and Cognitive Decline in a Mouse Model of Alzheimer's Disease.Nutrients · 2023Article
- Contribution of life course cardiovascular risk factors to racial disparities in dementia incidence.Frontiers in dementia · 2023Article
- A predictive coding framework of allostatic-interoceptive overload in frontotemporal dementia.Trends in neurosciences · 2022Review
- Association of life course adiposity with risk of incident dementia: a prospective cohort study of 322,336 participants.Molecular psychiatry · 2022Article
- Subjective cognitive decline and total energy intake: Talk too much?European journal of epidemiology · 2022Article
- Long-term trajectories and current BMI are associated with poorer cognitive functioning in middle-aged adults at high Alzheimer's disease risk.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline.Journal of Alzheimer's disease : JAD · 2021Article
- Body mass index, weight change in midlife, and dementia incidence: the Japan Public Health Center-based Prospective Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionTo examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.
methodsWe studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used.
resultsCompared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men.
conclusionsWith the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.
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Registered trials
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