ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
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29 citing papers in PubMed, 36 citations in OpenAlex.
- Brain microstructure mediates the relationship between Alzheimer's proteinopathies and memory.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Review
- Abnormal signal transmission in white matter revealed by resting-state communication connectivity in Alzheimer's disease: A comprehensive cross-sectional and longitudinal study.Translational psychiatry · 2026Article
- Association of neurite orientation dispersion and density imaging with cognitive impairment in nasopharyngeal carcinoma patients with radiation-induced temporal lobe injury.Frontiers in human neuroscience · 2026Article
- Intracellular fluid accumulation underlies brain volume increases in early Alzheimer's disease.Brain communications · 2026Article
- Assessing cognitive impairment in OSAHS patients through NODDI-based gray matter analysis.BMC neurology · 2025Article
- Analysis of advanced diffusion models assessing white matter microstructure in Alzheimer's disease.Scientific reports · 2025Article
- Associations between temporal lobe cortical NODDI measures and memory function in individuals without clinical dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognition.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.Molecular psychiatry · 2024Article
- Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease.Brain : a journal of neurology · 2024Article
- Cortical microstructural associations with CSF amyloid and pTau.Molecular psychiatry · 2024Article
- XAI-Based Assessment of the AMURA Model for Detecting Amyloid-β and Tau Microstructural Signatures in Alzheimer's Disease.IEEE journal of translational engineering in health and medicine · 2024Article
- Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping.Frontiers in neuroscience · 2024Article
- Structural Network Topology Reveals Higher Brain Resilience in Individuals with Preclinical Alzheimer's Disease.Brain connectivity · 2023Article
- Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status.Alzheimer's research & therapy · 2023Article
- Astrogliosis, neuritic microstructure, and sex effects: GFAP is an indicator of neuritic orientation in women.Brain, behavior, and immunity · 2023Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 5 countries.
Nicholas M VogtWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0002-2334-1495
Jack F V HuntWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Nagesh AdluruWaisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Yue MaWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Carol A Van HulleWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Douglas C Dean IiiWaisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Steven R KecskemetiWaisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nathaniel A ChinWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Cynthia M CarlssonWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Sanjay AsthanaWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Gwendlyn KollmorgenRoche Diagnostics GmbH, Penzberg, Germany.
Richard BatrlaRoche Diagnostics International AG, Rotkreuz, Switzerland.
Norbert WildRoche Diagnostics GmbH, Penzberg, Germany.
Katharina BuckRoche Diagnostics GmbH, Penzberg, Germany.
Henrik ZetterbergInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Andrew L AlexanderWaisman Laboratory for Brain Imaging and Behavior, Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Kaj BlennowInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Barbara B BendlinWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USRoche Pharma AG (Germany) · DESahlgrenska University Hospital · SERoche (Switzerland) · CH
Funding
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6MWisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5MWisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8MWisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SAGER, MARK · 2009 to 2018
$16.2MTrainingU54AI117924 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CRAVEN, MARK W. · 2014 to 2018
$11.3MINTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3MWaisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0MWhite matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3MAlgebraic Formulations for Characterizing Structural Brain Connectivity Changes and Pathology Transmission Networks in Preclinical Alzheimer's DiseaseRF1AG059312 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA, SINGH, VIKAS · 2019 to 2019
$1.8MMaximizing Power in AD Clinical Trials via Multimodal Machine LearningR01AG040396 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SINGH, VIKAS · 2012 to 2015
$1.1MManifold-valued statistical models for longitudinal morphometic analysis in preclinical Alzheimer's disease (AD)R01EB022883 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C, SINGH, VIKAS · 2016 to 2018
$995kBRAIN CONNECTIVITY AND THE ROLE OF MYELIN IN AUTISM SPECTRUM DISORDERSR00MH110596 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DEAN III, DOUGLAS CARL · 2019 to 2021
$743kNIAID NIH HHS U54 AI117924NIA NIH HHS F30 AG059346NIA NIH HHS F31 AG062116NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG040396NIA NIH HHS RF1 AG027161NIA NIH HHS RF1 AG059312NIBIB NIH HHS R01 EB022883NICHD NIH HHS U54 HD090256NIGMS NIH HHS T32 GM008692NIH HHS P30 AG033514 (to SA)NIMH NIH HHS R00 MH110596
Abstract
introductionNeurite orientation dispersion and density imaging (NODDI), a multi-compartment diffusion-weighted imaging (DWI) model, may be useful for detecting early cortical microstructural alterations in Alzheimer's disease prior to cognitive impairment.
methodsUsing neuroimaging (NODDI and T1-weighted magnetic resonance imaging [MRI]) and cerebrospinal fluid (CSF) biomarker data (measured using Elecsys® CSF immunoassays) from 219 cognitively unimpaired participants, we tested the main and interactive effects of CSF amyloid beta (Aβ)
resultsWe observed a significant CSF Aβ DISCUSSION: NDI is a particularly sensitive marker for early cortical changes that occur prior to gross atrophy or development of cognitive impairment.
Indexed as
Cerebral CortexProdromal SymptomsAgedAlzheimer DiseaseAmyloidAmyloid beta-PeptidesApolipoprotein E4BiomarkersDiffusion Magnetic Resonance ImagingFemaleHealthy VolunteersHumansMaleMiddle AgedNeuritesPeptide FragmentsAmyloidAmyloid beta-Peptidesamyloid beta-protein (40-42)Apolipoprotein E4BiomarkersPeptide Fragmentstau Proteinscerebrospinal fluid biomarkerscortical microstructurediffusionmagnetic resonance imagingneurite orientation dispersion and density imagingpreclinical
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